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The Limits of Reversibility from Ischemic Insult and Our Method of Prolonging Cerebral Survival

  • Jiro Suzuki
  • Kazuo Mizoi
  • Hisashi Abiko
  • Kuniaki Ogasawara
  • Masatoshi Oba
  • Takashi Yoshimoto
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)

Summary

Since the occurrence of an accident during surgery on a cerebral aneurysm in 1969, we have been aware of the fact that 20% mannitol may have possible protective effects on the ischemic brain. During the subsequent 18 years, we have investigated the effectiveness of mannitol on cerebral ischemia using various experimental models and applied these experimental results in clinical cases.

We further surmised that other drugs which are said to be free radical scavengers might also have protective effects in brain ischemia. We have consequently undertaken systemic tests of the effects of mannitol and various other drugs using our experimental animal models of brain ischemia. We have found that, not only mannitol, but also several other drugs have such protective effects. Moveover, the combined administration of certain of these drugs has proven to have remarkably reliable effects in protecting the brain against the ischemic cell damage.

Keywords

Cerebral Ischemia Cerebral Infarction Free Radical Scavenger Ischemic Brain Basilar Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jiro Suzuki
    • 1
  • Kazuo Mizoi
    • 1
  • Hisashi Abiko
    • 1
  • Kuniaki Ogasawara
    • 1
  • Masatoshi Oba
    • 1
  • Takashi Yoshimoto
    • 1
  1. 1.Division of Neurosurgery, Institute of Brain DiseasesTohoku University School of MedicineSendai, 980Japan

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