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NMDA Antagonists Inhibit Cortical Spreading Depression, But Accelerate the Onset of Neuronal Depolarization Induced by Asphyxia

  • R. Marrannes
  • E. De Prins
  • R. Willems
  • A. Wauquier
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)

Abstract

Cortical spreading depression (SD) is a transient massive change of the local cortical microenvironment, which spreads over the cortex at a rate of approximately 3 mm/min. Asphyxia can facilitate the elicitation of SD. It has been proposed that release of glutamate may play an important role in SD1 and hypoxia. Glutamate activates the N-methyl-D-aspartate (NMDA), quisqualate and kainate receptors. We investigated whether the NMDA receptor is involved in SD during normoxia using the non-competitive NMDA antagonists ketamine, phencyclidine and MK-801 and the competitive NMDA antagonist 2-amino-7-phosphonoheptanoate (2-APH). Additionally, we tested whether NMDA antagonists affect the DC and ionic changes during asphyxia.

Keywords

NMDA Receptor NMDA Antagonist Cortical Spreading Depression Spreading Depression Kainate Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Van Harreveld, A. J. Neurobiol. 9: 419–431, 1978.CrossRefGoogle Scholar
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    Marrannes, R. et al. ISn: Amery, W. and Wauquier, A., eds. The prelude to the migraine attack, Bailline Tindall, pp. 158–173, 1986.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. Marrannes
    • 1
  • E. De Prins
    • 1
  • R. Willems
    • 1
  • A. Wauquier
    • 1
  1. 1.Department of NeuropharmacologyJanssen PharmaceuticaBeerseBelgium

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