Blood Flow and Metabolism in Cortical Spreading Depression

  • Martin Lauritzen
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)


The changes of local cerebral metabolism and blood flow in association with spreading depression (SD) (Leao 1944a) have been extensively studied in the past. The main observations are that blood flow and metabolic rate increase during return to normal of the DC shift, and that these events are not of primary importance for the production of SD. Therefore, a motivation is needed to explain why these variables of brain function have been reexamined. The reason is the recent suggestion that the changes of cerebral blood flow during migraine attacks might be interpreted as secondary to cortical SD. This possibility has prompted a series of experimental studies in rats and cats during SD with the express purpose of correlating the cerebral blood flow changes in migraine and SD. This correspondence will be the main subject of the present paper.


Cerebral Blood Flow Migraine Attack Regional Cerebral Blood Flow Cortical Spreading Depression Spreading Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Martin Lauritzen
    • 1
  1. 1.Department of General Physiology and Biophysics Panum Institute & Laboratory of Clinical Neurophysiology RigshospitaletUniversity of CopenhagenDenmark

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