Anoxia Reversibly Inactivates Hippocampal Ca-Currents

  • K. Krnjević
  • Jean Leblond
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)


Evidence from intracellular recording and voltage-clamping in hippocampal slices indicates that brief anoxia (2–4 min) strongly depresses excitability and synaptic potentials by raising K conductance and inactivating Ca-currents. Both effects could be explained by a rise in intracellular free Ca2+.


Hippocampal Slice Intracellular Recording Synaptic Potential Hyperpolarizing Effect Increase Potassium Conductance 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • K. Krnjević
    • 1
  • Jean Leblond
    • 1
  1. 1.Anaesthesia Research DepartmentMcGill UniversityCanada

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