Microcirculation and Metabolism in Reversible and Irreversible Cerebral Ischemia
It is well known that adenylate charge and blood blow of the brain can almost completely recover following a transient ischemic insult (Siesjo, 1981; Hossmann, 1982; Raichle, 1983). In spite of this, serious neurological deficits occur very early in brain ischemia. To get a better understanding of this discrepancy the present studies were focused on the regional-microregional circulatory and metabolic changes occurring in the brain cortex in reversible and irreversible ischemia and upon recirculation or reoxygenation. New methods were developed to assess the severity of brain damage in vivo and to measure permanent alterations in respiratory activity of in situ cortical mitochondria.
KeywordsMiddle Cerebral Artery Middle Cerebral Artery Occlusion Cerebral Perfusion Pressure Brain Cortex Sham Control
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