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Microcirculation and Metabolism in Reversible and Irreversible Cerebral Ischemia

  • Eors Dora
  • Arisztid G. B. Kovach
  • Joel H. Greenberg
  • Kortaro Tanaka
  • Nicholas H. Gonatas
  • Martin Reivich
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)

Abstract

It is well known that adenylate charge and blood blow of the brain can almost completely recover following a transient ischemic insult (Siesjo, 1981; Hossmann, 1982; Raichle, 1983). In spite of this, serious neurological deficits occur very early in brain ischemia. To get a better understanding of this discrepancy the present studies were focused on the regional-microregional circulatory and metabolic changes occurring in the brain cortex in reversible and irreversible ischemia and upon recirculation or reoxygenation. New methods were developed to assess the severity of brain damage in vivo and to measure permanent alterations in respiratory activity of in situ cortical mitochondria.

Keywords

Middle Cerebral Artery Middle Cerebral Artery Occlusion Cerebral Perfusion Pressure Brain Cortex Sham Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Eors Dora
    • 1
    • 2
  • Arisztid G. B. Kovach
    • 1
    • 2
  • Joel H. Greenberg
    • 1
    • 2
  • Kortaro Tanaka
    • 1
    • 2
  • Nicholas H. Gonatas
    • 1
    • 2
  • Martin Reivich
    • 1
    • 2
  1. 1.Experimental Res. Dept. & 2nd Inst. of Physiol.Semmelweis Univ. Med. Sch.BudapestHungary
  2. 2.Cerebrovascular Res. Ctr., Dept. of NeurologyUniv. of Penn.PhiladelphiaUSA

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