The Dependency of Cerebral Ischemic Damage on Duration and Severity of Ischemia: Studies of Single Cell Activity and Multimodality Evoked Responses
Experiments with permanent and transient MCA occlusion in cats show that functional and structural deficits develop in the course of focal ischemia and postischemic reperfusion primarily in response to the degree of local blood flow reduction. However, other factors such as duration of ischemia, heterogeneity of residual blood flow, selective vulnerability of different neurons or brain regions, and remote deactivation caused by blood flow disturbances at other brain sites may influence the ischemic disturbance as well. We conclude therefore that with regard to the concept of flow thresholds for ischemic damage, the various factors have to be considered.
KeywordsFocal Ischemia Ischemic Core Selective Vulnerability Transient Middle Cerebral Artery Occlusion Single Unit Activity
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- Graf, R., Kataoka, K., Rosner, G., and Heiss, W.-D., 1987, Cortical deafferentation after MCA occlusion in the cat: Electrophysiological investigations in three different sensory systems, in “Cerebral Vascular Disease 6”, Meyer et al., eds, Elsevier Sci. Publ., Amsterdam, in press.Google Scholar
- Graf, R., Rosner, G., Kataoka, K., and Heiss, W.-D., 1984, Alphachloralose anesthesia effects on cortical evoked responses and single unit activity in the cat, Pflüg. Arch. (Suppl.) 402: R30Google Scholar
- Morawetz, R.B., Crowell, R.H., DeGirolami, U., Marcoux, F.W., Jones, T.H., and Halsey, J.H. Jr., 1979, Regional cerebral blood flow thresholds during cerebral ischemia, Fed. Proc. 38: 2493.Google Scholar
- Spielmeyer, W., 1922, Histopathologie des Nervensystems, Springer-Verlag, Berlin.Google Scholar