Ischemic Damage of Rat Hippocampus and Basal Ganglia: Light Microscopical and Biochemical Changes

  • Rainald Schmidt-Kastner
  • Wulf Paschen
  • Janus Szymas
  • Konstantin-Alexander Hossmann
Part of the Advances in Behavioral Biology book series (ABBI, volume 35)


Rats were subjected to 30 min severe forebrain ischemia using a modified four-vessel occlusion (4VO) model. Biochemical determinations and measurements of regional cerebral blood flow revealed injury of hippocampus and striatum. Morphological analysis showed a pattern of selective vulnerability in both structures. Concomitant immunohistochemical investigations revealed massive glial proliferation and extravasation of serum-albumin.


Mossy Fiber Ischemic Damage Forebrain Ischemia Transient Cerebral Ischemia Selective Vulnerability 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Rainald Schmidt-Kastner
    • 1
  • Wulf Paschen
    • 1
  • Janus Szymas
    • 1
  • Konstantin-Alexander Hossmann
    • 1
  1. 1.Abteilung für experimentelle NeurologieMax-Planck-Institut für Neurologische ForschungKöln 91 (Merheim)Germany

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