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Frequency Dependent Changes in Excitatory Synaptic Efficacy

  • Robert S. Zucker

Abstract

Chemical synapses are not static. The strength or efficacy of synaptic transmission is highly variable. One may measure synaptic efficacy by recording intracellularly the size of the postsynaptic potential (PSP, or EPSP at excitatory synapses) near the spike initiating zone. At some synapses, PSPs grow dramatically during repetitive stimulation to many times, even hundreds of times, the size of an isolated PSP. If this growth occurs quickly, within tens of milliseconds to a second during a tetanus, and decays afterwards just as quickly, it is called synaptic facilitation. If the growth in transmission develops gradually, requiring tens of seconds of continuous stimulation, it is referred to as potentiation or tetanic potentiation; its persistence and gradual decay after a tetanus is called post-tetanic potentiation (PTP). Enhanced synaptic transmission with a lifetime between potentiation and facilitation is sometimes called synaptic augmentation. At some synapses, potentiation can persist for hours or even days: then it is referred to as long term potentiation (LTP). In addition to the differences in timing that characterize facilitation, augmentation, potentiation and PTP, and LTP, there are differences in the physiological mechanisms underlying these processes.

Keywords

Synaptic Transmission Long Term Potentiation Neuromuscular Junction Transmitter Release Synaptic Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Robert S. Zucker
    • 1
  1. 1.Department of Physiology-AnatomyUniversity of CaliforniaBerkeleyUSA

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