Biotechnology and the Human Genome pp 131-147
High Resolution Electron Microscopy for Structure and Mapping
- Cite this paper as:
- Hainfeld J.F., Wall J.S. (1988) High Resolution Electron Microscopy for Structure and Mapping. In: Woodhead A.D., Barnhart B.J., Vivirito K. (eds) Biotechnology and the Human Genome. Basic Life Sciences, vol 46. Springer, Boston, MA
Electron microscopes are very valuable to the human genome project. Brookhaven’s Scanning Transmission Electron Microscope (STEM) is unique in many respects. It is like the National Synchrotron Light Source (NSLS) or the High Flux Beam Reactor (HFBR) at Brookhaven, but on a much smaller scale. The STEM uses electrons that are focussed through the sample, and detected. It is a scanning microscope because it scans the beam much like a television set. This is in contrast to most electron microscopes that are fixed beam, flood the sample with electrons, and then use a lens after the sample that reimages the material at higher magnification. There are some advantages of scanning, which I will describe.
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