Androgen Regulation of Gene Expression: Studies of Ornithine Decarboxylase in Murine Kidney
The action of androgenic steroids in their target tissues occurs in a receptor-mediated fashion similar to that of other steroid hormones. The details of steroid hormone action, as they are currently known, originate mainly from studies of glucocorticoids, estrogens, and progestins, despite the fact that the first and most convincing biological arguments for the importance of soluble receptors in the expression of steroid action are from studies of androgen resistance syndromes (1–3). There are several possible reasons that research on androgen action has lagged behind that of female sex steroids and glucocorticoids. These include problems in the measurement and purification of the androgen receptor; a relatively slow progress in isolation and characterization of androgen-responsive genes and their encoded products; and paucity of suitable experimental systems to study androgen action in cultured cells. Over the last several years, however, a number of gene products regulated by androgens have been characterized and their induction kinetics in vivo elucidated. The best defined of these genes/gene products fall, with regard to their tissues of expression, into three main categories: (i) α2u -globulin and the major urinary protein (MUP) genes are regulated by androgens in rodent liver (4–11); (ii) prostatein and seminal vesicle basic protein genes are controlled by androgens in rat accessory sex organs (12–19), and (iii) ornithine decarboxylase (ODC), β-glucuronidase, RP2, and kidney androgen-regulated protein (KAP) genes exhibit androgen regulation in murine kidney (20–31).
KeywordsAndrogen Receptor Ornithine Decarboxylase Mouse Kidney Major Urinary Protein Murine Kidney
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