Human Progesterone Receptors A and B: Two Independent, Functional Forms

  • Kathryn B. Horwitz
Part of the Serono Symposia, USA book series (SERONOSYMP)


The use of progesterone receptor (PR) measurements and progestins in the treatment of breast cancers (reviewed in reference 1) and the use of progesterone antagonists in contraception (2) has required an understanding of the actions of these hormones at a basic molecular level. To study the structure and function of human progesterone receptors (hPR), we have used T47Dco, a PR-rich human breast cancer cell line (3), and in situ photoaffinity labeling (4,5); we have also purified the PR from T47D cells and have made anti-PR monoclonal antibodies (6). This chapter describes some of our recent studies using these methods (7) to analyze the structure of hPR.


Progesterone Receptor T47D Cell Photoaffinity Label Steroid Binding Protein Progesterone Antagonist 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kathryn B. Horwitz
    • 1
  1. 1.Departments of Medicine and PathologyUniversity of Colorado Health Sciences CenterDenverUSA

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