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Structural Features and Clinical Significance of Estrogen Receptors

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Steroid Receptors in Health and Disease

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

An important question in molecular endocrinology is how structurally simple molecules, such as the steroid hormones, initiate the myriad of effects in a wide variety of target organs via their receptor proteins. It is generally accepted that a prerequisite for responsiveness to a steroid hormone stimulus is a cellular protein termed the steroid hormone receptor or steroid binding protein. These receptor proteins have been found in concentrations ranging from 50–50,000 sites per target cell but are virtually absent in nontarget cells. A biologically important property is the association of a steroid hormone with its characteristic receptor protein in a manner exhibiting both high affinity and ligand specificity.

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Author information

Authors and Affiliations

  1. Departments of Biochemistry, Hormone Receptor Laboratory, USA

    James L. Wittliff & Salman M. Hyder

  2. Departments of Medicine, Hormone Receptor Laboratory, USA

    Joseph C. Allegra

  3. Departments of Obstetrics and Gynecology, Hormone Receptor Laboratory, USA

    Thomas G. Day Jr.

  4. J. G. Brown Cancer Center, University of Louisville, Louisville, KY, 40292, USA

    James L. Wittliff, Joseph C. Allegra, Thomas G. Day Jr. & Salman M. Hyder

Authors
  1. James L. Wittliff
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  2. Joseph C. Allegra
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  3. Thomas G. Day Jr.
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  4. Salman M. Hyder
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Editor information

Editors and Affiliations

  1. Oakland University, Rochester, Michigan, USA

    Virinder K. Moudgil (Chairman) (Chairman)

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© 1988 Plenum Press, New York

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Wittliff, J.L., Allegra, J.C., Day, T.G., Hyder, S.M. (1988). Structural Features and Clinical Significance of Estrogen Receptors. In: Moudgil, V.K. (eds) Steroid Receptors in Health and Disease. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5541-0_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5541-0_21

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4684-5541-0

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