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Structural Features and Clinical Significance of Estrogen Receptors

  • James L. Wittliff
  • Joseph C. Allegra
  • Thomas G. DayJr.
  • Salman M. Hyder
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

An important question in molecular endocrinology is how structurally simple molecules, such as the steroid hormones, initiate the myriad of effects in a wide variety of target organs via their receptor proteins. It is generally accepted that a prerequisite for responsiveness to a steroid hormone stimulus is a cellular protein termed the steroid hormone receptor or steroid binding protein. These receptor proteins have been found in concentrations ranging from 50–50,000 sites per target cell but are virtually absent in nontarget cells. A biologically important property is the association of a steroid hormone with its characteristic receptor protein in a manner exhibiting both high affinity and ligand specificity.

Keywords

Estrogen Receptor High Performance Liquid Chromatography Endometrial Carcinoma Steroid Hormone Receptor Sucrose Density Gradient Centrifugation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • James L. Wittliff
    • 1
    • 4
  • Joseph C. Allegra
    • 2
    • 4
  • Thomas G. DayJr.
    • 3
    • 4
  • Salman M. Hyder
    • 1
    • 4
  1. 1.Departments of BiochemistryHormone Receptor LaboratoryUSA
  2. 2.Departments of MedicineHormone Receptor LaboratoryUSA
  3. 3.Departments of Obstetrics and GynecologyHormone Receptor LaboratoryUSA
  4. 4.J. G. Brown Cancer CenterUniversity of LouisvilleLouisvilleUSA

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