Steroid Receptors: A Historical Perspective
Receptor theory got its start over a century ago when Langley (1) proposed that tissues contained specific substances that combined with drugs to produce their effects. However, it was not until 1959 that the direct demonstration of tissue binding of a cell regulator was reported. Jensen and associates (2) and Glascock and Hoekstra (3) observed that target organs of the estrogens retained more labeled estrogen than nontarget organs after systemic administration of the labeled hormone. Thus was born the concept of the estrogen receptor and the whole field of experimental receptorology.
KeywordsSteroid Receptor Estrogen Action High Specific Activity Pyridine Nucleotide Steroid Hormone Action
Unable to display preview. Download preview PDF.
- 1.Langley JN. On the physiology of the salivary secretion. J Physiol (London) 1879; 1: 339–69.Google Scholar
- 2.Jensen EV, Jacobson HI. Fate of steroid estrogens in target tissues. In: Pincus G, Vollmer E, eds. Biological activities of steroids in relation to cancer. New York: Academic Press, 1960: 161–78.Google Scholar
- 4.Green DE. Enzymes and trace substances. In: Nord FF, ed. Advances in enzymology. New York: Interscience Publishers, Inc., 1941: 17–798.Google Scholar
- 7.Szego CM, Roberts S. Steroid action and interaction in uterine metabolism. Recent Prog Horm Res 1953; 8: 419–69.Google Scholar
- 15.Gorski J, Hansen J. The one and only step model of estrogen action. Steroids (in press).Google Scholar