Steroid Receptors: A Historical Perspective

  • Jack Gorski
Part of the Serono Symposia, USA book series (SERONOSYMP)


Receptor theory got its start over a century ago when Langley (1) proposed that tissues contained specific substances that combined with drugs to produce their effects. However, it was not until 1959 that the direct demonstration of tissue binding of a cell regulator was reported. Jensen and associates (2) and Glascock and Hoekstra (3) observed that target organs of the estrogens retained more labeled estrogen than nontarget organs after systemic administration of the labeled hormone. Thus was born the concept of the estrogen receptor and the whole field of experimental receptorology.


Steroid Receptor Estrogen Action High Specific Activity Pyridine Nucleotide Steroid Hormone Action 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jack Gorski
    • 1
  1. 1.Department of BiochemistryUniversity of WisconsinMadisonUSA

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