Nuclear Acceptor Sites: Interaction with Estrogen-Versus Antiestrogen-Receptor Complexes

  • Thomas S. Ruh
  • Mary F. Ruh
  • Raj K. Singh
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

Although it is generally accepted that an interaction between steroid hormone receptors and nuclear acceptor sites is necessary for steroid induction of gene expression, the components of specific nuclear acceptor sites are still being investigated. There have been numerous models for steroid receptor interaction with target cell nuclear components, such as binding to nuclear membranes, RNA, nuclear matrix, DNA sequences and acceptor protein-DNA complexes. None of these models are mutually exclusive of one another.

Keywords

Cellulose Estrogen Leukemia Hydrochloride Estrogen Antagonist 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Thomas S. Ruh
    • 1
  • Mary F. Ruh
    • 1
  • Raj K. Singh
    • 1
  1. 1.Department of PhysiologySt. Louis University School of MedicineSt. LouisUSA

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