Advances in Uterus Estradiol Receptor Phosphorylation on Tyrosine and Preliminary Evidences That Liver Glucocorticoid Receptor Might Be Phosphorylated on Tyrosine

  • G. Castoria
  • A. Migliaccio
  • M. Di Domenico
  • M. Pagano
  • A. Rotondi
  • E. Nola
  • F. Auricchio
Part of the Serono Symposia, USA book series (SERONOSYMP)


Our group has been working since 1979 on the process which reversibly regulates hormone binding of the uterus estradiol receptor. The possibility that phosphorylation of proteins is responsible for the hormone binding to steroid receptors was proposed for the first time for the glucocorticoid receptor when it was observed that ATP shortage of thymocytes decreases their ability to bind hormone whereas ATP recovery parallels recovery of this binding (1). Subsequently, it was observed that hormone binding to different steroid receptors is inactivated by exogenous phosphatases and reactivated by processes requiring ATP (2–4). Unfortunately, neither in the case of glucocorticoid receptor nor in the case of other steroid receptors was it proved that the observed fluctuations of hormone binding were due to phosphorylation-dephosphorylation of either receptors or receptor-related proteins.


Glucocorticoid Receptor Steroid Receptor Hormone Binding Receptor Preparation Antiphosphotyrosine Antibody 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. Castoria
    • 1
  • A. Migliaccio
    • 1
  • M. Di Domenico
    • 1
  • M. Pagano
    • 1
  • A. Rotondi
    • 1
  • E. Nola
    • 2
  • F. Auricchio
    • 1
  1. 1.II Cattedra di Patologia Generale Istituto di Patologia Generale, I Facolta di Medicina e ChirUniversita di NapoliItaly
  2. 2.I Cattedra di Istituzioni di Patologia Generale Istituto di Patologia Generale, I Facolta di Medicina e ChirUniversita di NapoliItaly

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