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Progress in Diagnostic Immunoscintigraphy and First Approach to Radioimmunotherapy of Colon Carcinoma

  • Jean-Pierre Mach
  • Franz Buchegger
  • Angelika Bischof-Delaloye
  • Sven Curchod
  • Ariane Studer
  • Pelham Douglas
  • Serge Leyvraz
  • Jean-Philippe Grob
  • Francois Mosimann
  • Jean-Claude Givel
  • Jacques Pettavel
  • Bernard Delaloye
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

More than thirty years ago, Pressman and Korngold (1953) and Bale and Spar (1957) reported the first experiments indicating that radiolabeled antibodies injected into a tumor bearing animal can localize preferentially into the tumor, which could be detected by external scanning. These early studies, however, were performed with poorly characterized antibodies obtained by absorption and elution from tumor cells or crude tumor fractions. Thus, this type of antibodies could not be used for clinical applications.

Keywords

Liver Metastasis Colon Carcinoma Intraarterial Injection Intact Antibody Tumor Bearing Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jean-Pierre Mach
    • 1
    • 2
    • 3
  • Franz Buchegger
    • 1
    • 2
    • 3
  • Angelika Bischof-Delaloye
    • 1
    • 2
    • 3
  • Sven Curchod
    • 1
    • 2
    • 3
  • Ariane Studer
    • 1
    • 2
    • 3
  • Pelham Douglas
    • 1
    • 2
    • 3
  • Serge Leyvraz
    • 1
    • 2
    • 3
  • Jean-Philippe Grob
    • 1
    • 2
    • 3
  • Francois Mosimann
    • 1
    • 2
    • 3
  • Jean-Claude Givel
    • 1
    • 2
    • 3
  • Jacques Pettavel
    • 1
    • 2
    • 3
  • Bernard Delaloye
    • 1
    • 2
    • 3
  1. 1.Institute of BiochemistryUniversity of LausanneEpalingesSwitzerland
  2. 2.Division of Nuclear MedicineDepartment of Surgery and RadiotherapyLausanneSwitzerland
  3. 3.Centre Pluridisciplinaire d’OncologieLausanneSwitzerland

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