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Development and Characterization of Human Monoclonal Antibodies and Their Application in the Radioimmunodetection of Colon Carcinoma

  • Conference paper
Book cover Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Part of the book series: NATO ASI Series ((NSSA,volume 152))

Abstract

Significant progress has been made in the application of monoclonal antibody technology to clinical diagnosis of cancer and to management of the disease. Antibodies labeled with radioactive isotopes have been demonstrated to localize in tumors of the gastrointestinal tract (1–6), ovary (6), breast (6,7), and skin (8) and promise to be very helpful in identifying metastases in patients with these tumors. However, there remain several problems to be resolved before radiolabeled antibody detection of tumor foci will be applied as an accepted and routine diagnostic/prognostic procedure. Problems include antibody cross-reactivity with normal tissues (5,6,9,10), low level penetration of antibody into tumor tissue (5,9,10), and inhibitory effects of specific circulating antigen (11). Current research is focused on selecting antibodies with the most desirable characteristics for tumor detection, improving chemistries to allow use of more appropriate radionuclides, and defining the effective clinical applications with regard to the tumor types, tumor sites and available diagnostic equipment and procedures.

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Author information

Authors and Affiliations

  1. Bionetics Research, Inc., Rockville, Maryland, USA

    Richard P. McCabe, Leona C. Peters, Martin V. Haspel, Nicholas Pomato & Jorge A. Carrasquillo

  2. Department of Nuclear Medicine, National Institutes of Health, Bethesda, Maryland, USA

    Jorge A. Carrasquillo

Authors
  1. Richard P. McCabe
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  2. Leona C. Peters
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  3. Martin V. Haspel
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  4. Nicholas Pomato
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  5. Jorge A. Carrasquillo
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Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Suresh C. Srivastava

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© 1988 Springer Science+Business Media New York

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McCabe, R.P., Peters, L.C., Haspel, M.V., Pomato, N., Carrasquillo, J.A. (1988). Development and Characterization of Human Monoclonal Antibodies and Their Application in the Radioimmunodetection of Colon Carcinoma. In: Srivastava, S.C. (eds) Radiolabeled Monoclonal Antibodies for Imaging and Therapy. NATO ASI Series, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5538-0_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5538-0_6

  • Publisher Name: Springer, Boston, MA

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