Monoclonal Antibody Against Human Fibrin for Imaging Thrombi

  • John G. McAfee
  • Zachary D. Grossman
  • Scott F. Rosebrough
  • Gopal Subramanian
  • Catherine Ritter-Hrncirik
  • Larry S. Witanowski
Part of the NATO ASI Series book series (NSSA, volume 152)


The detection and localization of venous thrombi, most common in the lower extremities and pelvis, remain a major diagnostic problem in clinical medicine. Although radiographic venography with contrast medium is highly sensitive and specific, the injections are frequently painful, and reactions from large doses of intravenous contrast media of varying severity occur. In the search for a less invasive diagnostic procedure, gamma camera imaging has been tried frequently, using a number of radioactive agents, including fibrinogen (1), split fibrin products (2,3), streptokinase, urokinase, plasminogen, plasmin (4), tissue plasminogen activator, and labeled platelets (5). Labeled fibrinogen fragment E was successful in pigs (4), but apparently less successful in human trials. Labeled platelets have consistently localized thrombi less than 12 hours old and even up to one day old, but older thrombi encountered in clinical practice are localized poorly (3). In general, the results of radionuclide imaging for thrombus detection have been disappointing. To attempt to improve the efficacy of camera imaging, we have explored the use of a labeled monoclonal antibody against human fibrin in a canine model.


Venous Thrombus Radiation Dose Estimate Fresh Thrombus Indium Chloride Gianturco Coil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • John G. McAfee
    • 1
  • Zachary D. Grossman
    • 1
  • Scott F. Rosebrough
    • 1
  • Gopal Subramanian
    • 1
  • Catherine Ritter-Hrncirik
    • 1
  • Larry S. Witanowski
    • 1
  1. 1.Divisions of Nuclear Medicine and Radiological Sciences Department of RadiologyS.U.N.Y. Health Science CenterSyracuseUSA

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