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Recent Perspectives on the Use of Radiolabeled Monoclonal Antibodies for Immunotherapy

  • Rashid A. Fawwaz
  • Theodore S. T. Wang
  • Suresh C. Srivastava
  • Rodney Bigler
  • Mark Hardy
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

Recent advances in hybridoma technology have led to the development of specific monoclonal antibodies to a variety of tumor-associated antigens. The high degree of specificity of such reagents has rekindled interest in their application to immunotherapy of malignancies. In-vitro culture studies and experiments in various in-vivo animal models have usually shown that monoclonal antibodies, even in the presence of complement, are rarely alone sufficiently cytotoxic and therefore usually ineffective for tumor destruction (1,2). This ineffectiveness of monoclonal antibodies when used in unmodified forms has been partially attributed to the heterologous distribution of tumor-associated antigens on tumor cell surfaces which therefore results in an insufficient attachment of monoclonal antibodies to different tumor cells; more to those cells which have a significant number of binding sites for the antigen but none to other tumor cells that are devoid of binding sites for the specific antigen (3). Thus, while tumor cells which express the specific antigen may under appropriate circumstances undergo lysis, those which are negative for the antigen are spared and continue to proliferate. Monoclonal antibodies directed to tumor-associated antigens which are coupled to various toxins suffer from the same shortcomings that have been described for unmodified antitumor monoclonal antibodies.

Keywords

Monoclonal Antibody Thyroid Carcinoma Follicular Thyroid Carcinoma Mouse Immunoglobulin Tumor Cell Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Rashid A. Fawwaz
    • 1
    • 2
  • Theodore S. T. Wang
    • 1
    • 2
  • Suresh C. Srivastava
    • 1
    • 2
    • 3
  • Rodney Bigler
    • 1
    • 2
    • 4
  • Mark Hardy
    • 1
    • 2
  1. 1.Department of Radiology College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Department of Surgery College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Medical DepartmentBrookhaven National LaboratoryUptonUSA
  4. 4.Division of Nuclear MedicineThe New York Hospital — Cornell Medical CenterNew YorkUSA

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