Advertisement

Monoclonal Antibodies Against Human Osteosarcoma: Preliminary Studies

  • O. Bruland
  • O. Fodstad
  • M. Aas
  • A. Pihl
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

Osteosarcoma is a highly malignant tumor that mainly affects young people. Until the introduction of the preoperative high-dose methotrexate treatment the prognosis was dismal. Even with current treatment many patients respond poorly to chemotherapy and rapidly develop metastases. Clearly, this is a disease where new approaches are sorely needed.

Keywords

Synovial Sarcoma Malignant Fibrous Histiocytoma Human Osteogenic Sarcoma Cell Line Distinct Image Freeze Tissue Section 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brown, J. M., 1983, Detection of a human sarcoma-associated antigen with monoclonal antibodies, Cancer Res., 43:2113.PubMedGoogle Scholar
  2. Bruland, O., Fodstad, O., Funderud, S., and Pihl, A., 1986, New monoclonal antibodies specific for human sarcomas, Int. J. Cancer, 37:27.CrossRefGoogle Scholar
  3. Bruland, O., Fodstad, O., Skretting, A., and Pihl, A., 1987, Selective localization of two radiolabeled anti-sarcoma monoclonal antibodies in human osteosarcoma xenografts, Brit. J. Cancer (in press).Google Scholar
  4. Embleton, M. J., Gunn, B., Byers, V. S., and Baldwin, R. W., 1981, Antitumor reactions of monoclonal antibody against a human osteogenic sarcoma cell line, Brit. J. Cancer, 43:582.PubMedCrossRefGoogle Scholar
  5. Hosoi, S., Nakamura, T., Higashi, S., Yamamuro, T., Toyama, S., Shinomiya, K. , and Mikawa, H. , 1982, Detection of human osteosarcoma-associated antigen(s) by monoclonal antibodies, Cancer Res., 42:654.PubMedGoogle Scholar
  6. Lindmo, T., Boven, E. , Cuttitta, F., Fedorko, J., and Bunn, Jr., P. A., 1984, Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess, J. Immun. Meth., 72:77.CrossRefGoogle Scholar
  7. Morton, D. L., and Malmgren, R. A., 1986, Human osteosarcomas: Immunological evidence suggesting an associated infectious agent, Science, 162:1279.CrossRefGoogle Scholar
  8. Mukherji, B., and Hirshaut, Y., 1973, Evidence for fetal antigens in human sarcoma, Science, 181:440.PubMedCrossRefGoogle Scholar
  9. Thorpe, W. P., and Rosenberg, S. A., 1979, Serologic analysis of human tumor antigens. I. Antisarcoma antibodies in the sera of patients with osteogenic sarcomas, J. Nat. Cancer Inst., 62:1143.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • O. Bruland
    • 1
  • O. Fodstad
    • 1
  • M. Aas
    • 1
  • A. Pihl
    • 1
  1. 1.The Norwegian Radium HospitalMontebelloNorway

Personalised recommendations