Selection of Monoclonal Antibodies with Optimal Biological Functions for Clinical Application
Murine monoclonal antibodies have been generated against a large number of human tumor associated antigens. These antibodies have been used to successfully detect circulating cancer antigens in patients’ blood (1) and to histologically identify the antigens on the surface of tumor cells (2). Antibodies conjugated with radioactive isotopes have been used extensively in preliminary investigations to localize tumor in cancer patients (3,4). In addition, there has been a great deal of current interest in the potential applications of these antibodies in the therapy of human cancer.
KeywordsTumor Cell Lysis Antibody Dependent Cell Mediate Cytotoxicity Xenografted Nude Mouse IgG2a Antibody Switch Variant
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