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Selection of Monoclonal Antibodies with Optimal Biological Functions for Clinical Application

  • John Powe
  • Michael Lubeck
  • Zenon Steplewski
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

Murine monoclonal antibodies have been generated against a large number of human tumor associated antigens. These antibodies have been used to successfully detect circulating cancer antigens in patients’ blood (1) and to histologically identify the antigens on the surface of tumor cells (2). Antibodies conjugated with radioactive isotopes have been used extensively in preliminary investigations to localize tumor in cancer patients (3,4). In addition, there has been a great deal of current interest in the potential applications of these antibodies in the therapy of human cancer.

Keywords

Tumor Cell Lysis Antibody Dependent Cell Mediate Cytotoxicity Xenografted Nude Mouse IgG2a Antibody Switch Variant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • John Powe
    • 1
  • Michael Lubeck
    • 1
  • Zenon Steplewski
    • 1
  1. 1.The Wistar InstitutePhiladelphiaUSA

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