NMR Enhancement with Gd Labeled Antibodies

  • W. C. Eckelman
  • M. Tweedle
  • M. J. Welch
Part of the NATO ASI Series book series (NSSA, volume 152)


With the development of monoclonal antibodies, the hope of a magic bullet has been revived. Many therapeutic and diagnostic agents have been linked to monoclonal antibodies in order to add specificity to the process. Few of these combinations have reached their clinical potential. One such proposal deals with the combination of an antibody with a new image enhancing agent, a paramagnetic compound, for use with nuclear magnetic resonance (NMR) imaging. There are a number of ways that a diagnostic image can be enhanced by a chemical (Table 1).


Bifunctional Chelate 99mTc DTPA Paramagnetic Substance Polyglutamic Acid Paramagnetic Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • W. C. Eckelman
    • 1
  • M. Tweedle
    • 1
  • M. J. Welch
    • 1
    • 2
  1. 1.The Squibb Institute for Medical ResearchPrincetonUSA
  2. 2.Washington University Medical SchoolSt. LouisUSA

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