Comparative Prospective Detection of Recurrences of Carcinomas with SPECT Imaging Using Radiolabeled Monoclonal Antibodies, Ultrasonography and Computed Tomography

  • Jean-Francois Chatal
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)


Generally, when there is a recurrence after initial treatment of a carcinoma, prognosis is poor because of the limited efficacy of the different therapeutic alternatives. The diagnosis is often too late to allow complete surgical resection, and chemotherapy, whether associated with radiotherapy or not, has then only a transient palliative effect. It is thus important to make the diagnosis of recurrence earlier, before clinical signs appear, in the hope of providing complete surgical resection.


SPECT Imaging Tumor Uptake Complete Surgical Resection Antigenic Site Sulfur Colloid 


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  1. 1.
    G. D. Bowie, Ultrasound of gynecologic pelvic masses: the indefinite uterus and other patterns associated with diagnostic error, J. Clin. Ultrasound 5:323 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    R. C. Sanders, B. J. McNeil, H. J. Finberg, S. J. Hessel, S. S. Siegelman, D. F. Adams, P. O. Alderson, H. L. Abrams, A prospective study of computed tomography and ultrasound in the detection and staging of pelvic masses, Radiology 146:439 (1983).PubMedGoogle Scholar
  3. 3.
    D. E. Brenner, M. I. Shaff, H. W. Jones, W. W. Grosh, F. A. Greco, L. S. Burnett, Abdominopelvic computed tomography: evaluation in patients undergoing second-look laparotomy for ovarian carcinoma, Obstet. Gyneacol. 65:715 (1985).Google Scholar
  4. 4.
    H. Mantora, I. Isherwood, Computed tomography in ovarian carcinoma: patterns of disease and limitations, Clin. Radiol. 33:165 (1982).CrossRefGoogle Scholar
  5. 5.
    R. J. Johnson, G. Blackledge, B. Eddieston, D. Crowther, Abdomino-pelvic computed tomography in the management of ovarian carcinoma, Radiology 146:447 (1983).PubMedGoogle Scholar
  6. 6.
    J. Y. Douillard, P. A. Lehur, G. Aillet, M. Kremer, A. Bianco-Arco, P. Peltier and J. F. Chatal, Immunohistochemical antigenic expression and in vivo tumor uptake of monoclonal antibodies with GI tract tumor specificity, Cancer Research (1986) (in press).Google Scholar
  7. 7.
    B. A. Rhodes, D. J. Burke, K. Breslow, K. Reed, R. Austin, S. W. Burchiel, Effects of circulating antigen on antibody localization in vivo, in: “Radioimmunoassay and Radioimmunotherapy, ” S. W. Burchiel and B. A. Rhodes, eds., Elsevier Science Publishing Co., New York, pp. 26–39 (1983).Google Scholar
  8. 8.
    R. L. Wahl, C. W. Parker, G. W. Philpott, Improved radioimaging and tumor localization with monoclonal F(ab’)2, J. Nucl. Med. 24:316 (1983)PubMedGoogle Scholar
  9. 9.
    B. Delaloye, A. Bischof-Delaloye, F. Buchegger, V. Von Fliedner, J. P. Grob, J. C. Volant, J. Pettavel, J. P. Mach, Detection of colorectal carcinoma by emissioncomputerized tomography after injection of I-123-labeled Fab or F(ab’)2 fragments from monoclonal anti-carcinoembryonic antigen antibodies, J. Clin. Invest. 77:301 (1986).PubMedCrossRefGoogle Scholar
  10. 10.
    C. Mainguene, G. Aillet, M. Kremer, J. F. Chatal, Immunohistochemical study of ovarian tumors using the OC 125 monoclonal antibody as a basis for potential in vivo and in vitro applications, J. Nucl. Med. All. Sci. 30:19 (1986).Google Scholar
  11. 11.
    A. A. Epenetos, G. Hooker, H. Durbin, W. F. Bodmer, D. Snook, R. Begent, R. T. D. Oliver, J. P. Lavender, Indium-111 labelled monoclonal antibody to placental alkaline phosphatase in the detection of neoplasms to testis, ovary, and cervix, Lancet ii:350 (1985).CrossRefGoogle Scholar
  12. 12.
    M. Granowska, J. Shepherd, K. E. Britton, B. Ward, S. Mather, J. Taylor-Papadimitriou, A. A. Epenetos, M. J. Carroll, C. C. Nimmon, L. A. Hawkins, M. Slevin, W. Flatman, T. Home, J. Burchell, H. Durbin, and W. Bodmer, Ovarian cancer: diagnosis using I-123 monoclonal antibody in comparison with surgical findings, Nucl. Med. Commun. 5:485 (1984).PubMedCrossRefGoogle Scholar
  13. 13.
    S. E. Halpern, P. L. Hagan, P. R. Garver, J. A. Koziol, A. W. N. Chen, J. M. Frincke, R. M. Bartholomew, G. S. David, and T. H. Adams, Stability, characterization and kinetics of In-111-labeled monoclonal anti-tumor antibodies in normal animals and nude mouse-human tumor models, Cancer Res. 43:5347 (1983).PubMedGoogle Scholar
  14. 14.
    J. F. Chatal, Detection des tumeurs par anticorps monoclonaux radioraarques en tomoscintigraphie, Presse Med. 12:2361 (1983).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Jean-Francois Chatal
    • 1
  1. 1.University of Nantes U.211 INSERMNantesFrance

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