Quantitative Imaging and Internal Radiation Dosimetry in the Therapeutic Use of Labeled Monoclonal Antibodies
Before radionuclide immunotherapy can be carried out, the radiation dose to the target and to the normal tissues of the patient ought to be calculated. This is to ensure that the doses involved are likely to destroy the cells of the target while not being of a level likely to harm the patient. The internal radiation dosimetry requires knowledge of the activity in various “sensitive” organs and in the target volume as an absolute measurement in Becquerels. In the past, the term “quantitative” has often been used to signify a numerical estimate of the count or count rate in one part of the body relative to another reference part of the body. While this concept is useful in estimating time changes in activity distributions if the spatial rearrangement of activity is not too gross, it does not fulfill the requirements of estimating the dose received by an organ. Reasons for this include the fact that counts within an area of an image, though obviously related to the activity in the region, are subject to a number of distortions that are characteristic of the imaging equipment used in nuclear medicine. These are discussed in this paper.
KeywordsRadiation Dose Dose Rate Positron Emitter Tomograph Posterior View Beta Emitter
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