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In Vivo Kinetics of 131I-Monoclonal Antibodies [anti-CEA and 19-9, F(ab′)2] in Humans

  • Carlo Aprile
  • Raffaella Saponaro
  • Maurizio Villa
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

The use of radioiodinated immunococktail against CEA and CA 19-9 has been reported by Chatal et al. (1984, 1985) to improve the detection of malignancies from the gastrointestinal tract. The aim of this work was to study the scintigraphic kinetics of the tracer and the effects of circulating antigens on the pharmacokinetics of the monoclonal antibodies (MoAbs).

Keywords

Blood Clearance Whole Body Blood Radioactivity Effective Retention Antibody Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chatal, J. F., Saccavini, J. C., Fumoleau, P., Douillard, J. Y., Curtel, C., Kremer, M., LeMevel, B., and Koprowski, H., 1984, Immunoscintigraphy of colon carcinoma, J. Nucl. Med., 25:307.PubMedGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Carlo Aprile
    • 1
  • Raffaella Saponaro
    • 1
  • Maurizio Villa
    • 1
    • 2
  1. 1.Fondazione Clinica del LavoroNuclear Medicine ServicePaviaItaly
  2. 2.CIS DiagnosticiSanthiaItaly

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