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Antibody — Carboxypeptidase G2 Conjugates as Potential Tumour Imaging Agents

  • R. G. Melton
  • F. Searle
  • C. Bier
  • J. A. Boden
  • R. B. Pedley
  • A. J. Green
  • K. D. Bagshawe
  • R. F. Sherwood
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

Although monoclonal antibodies (Moab) are useful for delineating small residual deposits of tumor, radioimmunolocalization (RIL) in humans would be greatly improved if nonlocalizing antibody was removed from the blood pool more effectively, and uptake of antibody in other tissues, particularly by hepatic Fc receptors, was reduced.

Keywords

Blood Pool Tumor Uptake Disulphide Bond Specific Radioactivity Hepatic Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R. H. J. Begent, Biochim. Biophys. Acta 780:151–166 (1985).PubMedGoogle Scholar
  2. 2.
    F. Searle, T. Adam, and J. A. Boden, Cancer Immunol. Immunother. 21:205–208 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    R. F. SHERWOOD, R. G. Melton, S. M. Alwan and P. Hughes, Eur. J.Biochem. 148:447–453 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    F. Searle, C. S. Partridge, A. Kardana, A. J. Green, R. G. Buckley, R. H. J. Begent and G. A. Rawlins, Int. j . Cancer 33:429–434 (1984).PubMedCrossRefGoogle Scholar
  5. 5.
    R. G. Melton, C. N. Wiblin, A. Baskerville, R. L. Foster and R. F. Sherwood, Biochem. Pharmacol. (in press).Google Scholar
  6. 6.
    J. Carlsson, D. Drevin and R. Axen, Biochem. J., 173:723–737 (1978).PubMedGoogle Scholar
  7. 7.
    T. Kitagawa and T. Aikawa, J. Biochem., 79:233–236 (1976).PubMedGoogle Scholar
  8. 8.
    F. Searle, C. Bier, R. G. Buckley, S. Newman, R. B. Pedley, K. D. Bagshawe, R. G. Melton, S. M. Alwan and R. F. Sherwood, Br. J. Cancer 53:377–384 (1986).PubMedCrossRefGoogle Scholar
  9. 9.
    F. Searle, J. A. Boden, J. C. M. Lewis and K. D. Bagshawe, Br. J. Cancer 44:137–144 (1981).PubMedCrossRefGoogle Scholar
  10. 10.
    P. E. Thorpe, W. C. J. Ross, A. N. F. Brown, C. D. Myers, A. J. Cumber, B. M. J. Foxwell and J. A. Forrester, Eur. J. Biochem. 140:63–71 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    I. S. Trowbridge and D. L. Domingo, Nature (Lond)., 294:171–173 (1981).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • R. G. Melton
    • 1
  • F. Searle
    • 2
  • C. Bier
    • 2
  • J. A. Boden
    • 2
  • R. B. Pedley
    • 2
  • A. J. Green
    • 2
  • K. D. Bagshawe
    • 2
  • R. F. Sherwood
    • 1
  1. 1.Microbial Technology LaboratoryPHLS Centre for Applied Microbiology and ResearchSalisburyUK
  2. 2.Department of Medical OncologyCharing Cross HospitalLondonUK

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