Use of an Animal Model System for Evaluating Labeled Monoclonal Antibodies

  • Fyllis L. Otsuka
  • Michael J. Welch
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)


Radiolabeled antibodies have received much attention as to their possible use in tumor imaging and in tumor therapy.1–4 The early studies by Pressman and co-workers suggested that these reagents could localize in tumors and, therefore, could be used for tumor imaging.5,6 Since that time, there have been numerous other reports describing their use for this purpose.7–9 Because these studies used polyclonal antibodies, there was much concern over the large amount of nonspecific binding that was observed. To eliminate this problem, background subtraction techniques10 were developed to make the specific uptake in the target tissue more distinct.


Saturation Effect Label Antibody Liver Uptake Lung Uptake Intact Antibody 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Fyllis L. Otsuka
    • 1
  • Michael J. Welch
    • 1
  1. 1.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. LouisUSA

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