Biokinetic Studies and Scintigraphic Imaging of Human Carcinoma Xenografts with Radiolabeled Monoclonal Antibodies

  • R. Senekowitsch
  • H. Kriegel
  • R. P. Baum
  • G. Hör
Part of the NATO ASI Series book series (NSSA, volume 152)


Radiolabeled antibodies against tumor-associated antigens have been demonstrated to localize specifically in human carcinoma xenografts in experimental animals by tissue distribution studies and scintigraphy (1–6). The use of the whole IgG is associated with a prolonged circulation of the activity in the blood pool resulting in low activity concentration ratios between tumor and surrounding tissue. Antibody fragments showed a significantly faster clearance from the blood pool and improved tumor-to-tissue ratios compared to the intact antibody (7–10). The tumor uptake and the biological half-life in the tumor, however, are much higher for the intact antibody than for the fragments.


Nude Mouse Blood Pool Tumor Uptake Antibody Fragment Scintigraphic Image 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • R. Senekowitsch
    • 1
  • H. Kriegel
    • 1
  • R. P. Baum
    • 2
  • G. Hör
    • 2
  1. 1.Department of Nuclear BiologyGSUNeuherberg, MunichGermany
  2. 2.Department of Nuclear MedicineUniversity of FrankfurtFrankfurtGermany

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