Abstract
Antibodies can be used to carry radionuclides to tumors for in vivo diagnosis and treatment. Monoclonal antibody reagents have virtually replaced the heterosera of earlier days. When suitably radiolabeled, these antibodies provide potential for imaging and treatment of cancer. The potential of radioimmunoimaging and radioimmunotherapy of cancer based upon monoclonal antibodies has excited the scientific community. These developments provide a unique opportunity for radionuclide imaging based on the specificity of monoclonal antibodies and therapy based on treatment planning techniques analogous to those used in external beam and radionuclide sealed source radiation therapy. Our goal has been to develop a comprehensive treatment planning system for clinical cancer therapy with radiolabeled monoclonal antibodies against cancer-associated antigens. We expect the system to provide estimates of the radiation dose distributions associated with various choices of radionuclide and targeting molecule. These approaches are now feasible because of advances in quantitative radionuclide imaging. Tracer techniques can now be implemented by advanced equipment for quantitative radionuclide imaging and strengthened by dynamic modeling of the physiological parameters which govern radionuclide distribution, and hence radiation dose distribution (1). We believe that quantitative radionuclide imaging is necessary to efficiently and accurately make decisions that can influence the efficacy of radioimmunoimaging and radioimmunotherapy.
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References
G. L. DeNardo, A. Raventos, H. H. Hines, P. O. Scheibe, D. J. Macey, M. T. Hayes and S. J. DeNardo, Requirements for a treatment planning system for radioimmunotherapy, Internatl. J. Rad. Onc. Biol. Phys. 11:335–345 (1985).
J. A. Carrasquillo, K. A. Krohn, P. Beaumier, R. W. McGuffin, J. P. Brown, K. E. Hellstrom, I. Hellstrom, S. M. Larson, Diagnosis of and therapy for solid tumors with radiolabeled antibodies and immune fragments, Cancer Treat. Repts. 68:317–328 (1984).
J-F. Chatal, J-C. Saccavini, P. Fumoleau, J-Y. Douillard, C. Curtet, M. Kremer, B. Le Mevel, H. Koprowski, Immunoscintigraphy of colon carcinoma, J. Nuc. Med. 25:307–314 (1984).
F. H. DeLand, D. M. Goldenberg, In vivo cancer diagnosis by radioimmunodetection, in: Radioimmunoimaging and Radioimmunotherapy, S.W. Burchiel and B.A. Rhodes, eds, Elsevier, New York (1983).
G. L. DeNardo, S. J. DeNardo, D. J. Macey, Cancer treatment with radioactive labeled antibodies, in: Nuclear Medicine in Clinical Oncology, C. Winkler, ed., Springer-Verlag, Berlin, Heidelberg (1986).
A. A. Epenetos, Clinical results with regional antibodyguided irradiation, Cancer Drug Delivery 2:233 (1985).
A. A. Epenetos, S. Mather, M. Granowska, C. C. Nimmon, L. R. Hawkins, K. E. Britton, J. Shepherd, J. Taylor-Papadiminitriou, H. Durbin, J. S. Malpas, W. F. Bodmer, Targeting of Iodine-123 labeled tumor- associated monoclonal antibodies to ovarian, breast and gastrointestinal tumors, Lancet 2:999–1004 (1982).
A. L. Epstein, A. M. Zimmer, S. M. Spies, S. Mills, G. DeNardo, S. DeNardo, Radioimmunodetection of human B cell lymphomas with a radiolabeled tumor-specific monoclonal antibody (Lym-1), in: Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances, F. Cavalli, G. Bonadonna, M. Rozencweig, eds., Martinus Nijhoff Publishing, Boston (1985).
D. M. Goldenberg, F. DeLand, E. Kim, S. Bennett, F. J. Primus, J. R. van Nagell, N. Estes, P. DeSimone, P. Rayburn, Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning, New Eng. J. Med. 298: 1384–1388 (1978).
S. E. Halpern, R. O. Dillman, K. F. Witztum, J. F. Shega, P. L. Hagan, W. M. Burrows, J. B. Dillman, M. L. Clutter, R. E. Sobol, J. M. Frincke, R. M. Bartholomew, G. S. David, D. J. Carlo, Radioimmunodetection of melanoma utilizing In-111 96.5 monoclonal antibody: A preliminary report, Radiology 155:493–499 (1985).
J-P. Mach, J-F. Chatal, J-D. Lumbroso, F. Buchegger, M. Forni, J. Ritschard, C. Berche, J-Y. Douillard, S. Carrel: Tumor localization in patients by radiolabeled antibodies against colon carcinoma, Cancer Res. 43:5593–5600 (1983).
J. L. Murray, M. G. Rosenblum, R. E. Sobol, R. M. Bartholomew, C. E. Plager, T. P. Haynie, M. F. Jahns, J. H. Glenn, L. Lamki, R. S. Benjamin, N. Papadoupoulos, A. W. Boddie, J. M Frincke, G. S. David, D. J. Carlo, E. M. Hersh, Radioimmunoimaging in malignant melanoma with In-labeled monoclonal antibody 96.5, Cancer Res. 45:2376–2381 (1985).
L. F. O’Grady, G. L. DeNardo, S. J. DeNardo, Radiolabeled monoclonal antibodies for the detection of cancer, Am. J. Physiologic Imaging 1:44–53 (1986).
S. E. Order, Monoclonal antibodies: Potential role in radiation therapy and oncology, Internatl. J. Rad. Onc. Biol. Phys. 8:1193–1201 (1982).
M. G. Rosenblum, J. L. Murray, T. P. Haynie, H. J. Glenn, M. F. Jahns, R. S. Benjamin, J. M. Frincke, D. J. Carlo, E. M. Hersh, Pharmacokinetics of 111-In labeled anti-P97 monoclonal antibody in patients with metastatic malignant melanoma, Cancer Res. 45:2382–2386 (1985).
G. L. DeNardo, S. J. DeNardo, J-S. Peng, L. F. O’Grady, S. L. Mills, A. L. Epstein, R. D. Cardiff, Evidence of a saturable hepatic receptor for mouse monoclonal antibodies, J. Nuc. Med. 26:67 (1985).
S. J. DeNardo, G. L. DeNardo, L. F. O’Grady, J-S. Peng, D. J. Macey, S. L. Mills, R. D. Cardiff, A. L. Epstein, Human Kinetic distribution of I-123 intact antibody, J. Nuc. Med. 26:112 (1985).
K. Koizumi, G. L. DeNardo, S. J. DeNardo, J-S. Peng, D. J. Macey, K. Hisada, N. Tonami, Multicompartmental analysis of the kinetics of monoclonal antibody in cancer patients, J. Nuc. Med. 26:91 (1985).
S. J. DeNardo, G. L. DeNardo, J-S. Peng, D. Colcher, Monoclonal antibody radiopharmaceuticals for cancer radioimmunotherapy, in: Radioimmunoimaging and Radioimmunotherapy, S. Burchiel, B. Rhodes, eds., Elsevier, New York (1983).
D. J. Macey, R. Marshall, The lungs, in: Computed Emission Tomography, P. J. Ell and B. L. Holman, eds., Oxford University Press, New York, Toronto, pp. 495–520, 1982
A. L. Epstein, R. J. Marder, J. N. Winter, E. Stathopoulos, F-M. Chen, J. W. Parker, C. R. Taylor, Two new monoclonal antibodies, Lym-1 and Lym-2, reactive with human B lymphocytes and derived tumors with immunodiagnostic and immunotherapeutic potential, Cancer Res. In press.
D. J. Macey, R. Marshall, Absolute quantitation of radiotracer up-take in the lungs using a gamma camera, J. Nuc. Med. 23:731–734 (1982).
D. J. Macey, G. L. DeNardo, S. J. DeNardo, H. H. Hines, Comparison of low- and medium-energy collimators for SPECT imaging with Iodine-123 labeled antibodies, J. Nuc. Med. 27:1467–1474 (1986).
F. B. Atkins, R. N. Beck, P. B. Hoffer, D. Palmer, Dependence of optimum baseline setting on scatter fraction and detector response function in medical radionuclide imaging, IAEA, Vienna (1977).
J. W. Beck, R. J. Jaszczak, R. E. Coleman, C. F. Starmer, L. W. Nolte, Analysis of SPECT including scatter and attenuation using sophisticated Monte Carlo modeling methods, IEEE Trans. Nuc. Sci. 506–511 (1982).
T. F. Budinger, S. E. Derenzo, W. L. Greenberg, G. T. Gullberg, R. H. Huesman, Quantitative potentials of dynamic emission computed tomography, J. Nuc. Med. 19:309–315 (1978).
T. F. Budinger, G. T. Gullberg, Transverse section reconstruction of gamma-ray emitting radionuclides in patients, in: Reconstruction Tomography in Diagnostic Radiology and Nuclear Medicine, M. M Ter-Pogossian, M. E. Phelps, G. L. Brownell et al., eds., University Park Pres, Baltimore (1977).
R. J. Jaszczak, L. T. Chang, N. A. Stein, F. E. Moore, Whole body single-photon emission computed tomography using dual, large-field-of-view scintillation cameras, Phys. Med. Biol. 24:1123–1143 (1979).
R. J. Jaszczak, R. E. Coleman, F. R. Whitehead, Physical factors affecting quantitative measurements using camera based SPECT, IEEE Trans. Nuc. Sci. 28:69–80 (1981).
J. W. Keyes, Perspectives on tomography, J. Nuc. Med. 23:633–640 (1982).
G. Muehllehner, J. G. Colsher, E. W. Stoub, Correction for field non-uniformity in scintillation camera through removal of spatial distortion, J. Nuc. Med. 21:771–776 (1980).
M. E. Phelps, Emission computed tomography, Seminars in Nuc. Med. 7:337–365 (1977).
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DeNardo, G.L., DeNardo, S.J., Macey, D.J., Mills, S.L. (1988). Quantitative Pharmacokinetics of Radiolabeled Monoclonal Antibodies for Imaging and Therapy in Patients. In: Srivastava, S.C. (eds) Radiolabeled Monoclonal Antibodies for Imaging and Therapy. NATO ASI Series, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5538-0_21
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DOI: https://doi.org/10.1007/978-1-4684-5538-0_21
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