Potential Labeling of Monoclonal Antibodies with Positron Emitters

  • Michael J. Welch
  • Michael R. Kilbourn
Conference paper
Part of the NATO ASI Series book series (NSSA, volume 152)


The use of gamma-emitting radiolabeled antibodies as diagnostic imaging agents had produced promising results. Positron emission tomography has advantages in areas of resolution, quantification, and sensitivity over conventional γ-imaging. There are two approaches to labeling antibodies with positron-emitting nuclides. In one approach, a long-lived radionuclide such as zirconium-89 (half-life 78 hr) has been suggested as a label for monoclonal antibodies (1). Bromine-76 (2), which has been used to label ligands for the dopamine receptor, could also be used and techniques developed for labeling proteins (3–5) with bromine-77 adapted to this application. Table 1 gives some relevant nuclear data concerning these and other potentially useful positron-emitting radionuclides. Although there are other candidate positron-emitting radionuclides, the ones listed in Table 1 can be used using currently available labeling technology.


Progressive Supranuclear Palsy Label Antibody Parathyroid Tissue Phenacyl Bromide Tetrabutylammonium Hydroxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Michael J. Welch
    • 1
  • Michael R. Kilbourn
    • 1
  1. 1.Division of Radiation SciencesWashington University School of MedicineSt. LouisUSA

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