Abstract
A remarkably large number of metallic ions form “stable” chelate complexes with certain organic molecules (chelators, or ligands). For example, diligent — but probably incomplete — searching of the literature reveals references to the preparation and/or thermodynamic stability constants of the chelates of about 70 different elements with the chelator EDTA (1,2). These elements (Figure 1) have a great range of properties; included are radionuclides suitable for medical diagnosis and therapy, as well as paramagnetic, chemically reactive, or luminescent metals appropriate to other applications. Since many of these elements have only moderate stability as EDTA chelates, there are good reasons to search for new chelators that will permit particular metals to be used in vivo as probes or cell-killing agents.
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Meares, C.F. (1988). Use of Bifunctional Chelating Agents for Radiolabeling Antibodies. In: Srivastava, S.C. (eds) Radiolabeled Monoclonal Antibodies for Imaging and Therapy. NATO ASI Series, vol 152. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5538-0_17
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DOI: https://doi.org/10.1007/978-1-4684-5538-0_17
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