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Production and Use of Prospective Radionuclides for Radioimmunotherapy

  • Leonard F. Mausner
  • Rita F. Straub
  • Suresh C. Srivastava
Part of the NATO ASI Series book series (NSSA, volume 152)

Abstract

The potential of utilizing monoclonal antibodies (Mab) as carriers of radionuclides for the selective destruction of tumors has stimulated much research activity. The approach should be most beneficial for treatment of tumors not easily amenable to surgical control, for treatment of early recurrence and of distant metastases. Even though significant progress has been made, more work will be necessary to understand the various chemical and biological factors which can influence antibody specificity, stability and kinetics, as well as dosimetric considerations for effective therapy. The choice of radiolabel is an important factor that needs to be optimized to allow the modality to fulfill its potential. For immunoscintigraphy, I-123, I-131, In-111, and Tc-99m have all been used with some success. However, almost all therapeutic trials have utilized I-131. This is largely due to its ready availability at moderate cost, the ease of halogenation techniques for proteins, and its long history of use in treating thyroid malignancy, rather than any careful analysis of its suitability for radioimmunotherapy.

Keywords

Excitation Function Dose Ratio Product Element Beta Emission Label Chemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Leonard F. Mausner
    • 1
  • Rita F. Straub
    • 1
  • Suresh C. Srivastava
    • 1
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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