Evidence for Contrasuppression in Patients with Crohn’s Disease
Vicia villosa agglutinin (WA) is a lectin that binds specifically to glycoconjugates with terminal N-acetyl-galactose. Originally murine T cells binding to WA are reported to be involved in cytotoxicity (l) however this has been contradicted by others (2,3). Moreover murine and human T cells reacting with WA were suggested to be involved in contrasuppression (4–7). T cells displaying contrasuppressor activity inhibit the action of suppressor cells on helper cells, thus enhancing immune response. Beside binding sites for VVA, contrasuppressor T cells in mice express Lyt-2(corresponding to CD8, contrasuppressor inducer), Lyt-1 (corresponding to CD4, contrasuppressor effector) or both determinants (contrasuppressor acceptor or transducer cells). Additionally I-J determinants are exhibited that are however different from those found on feedback suppressor cells (8).It has been suggested that contrasuppression is responsible for regulation of local immune response in particular in the gut mucosa (5). Alterations in contrasuppression have further been suspected to be involved in autoimmunity (9)f although experimental data to support this thesis are sparse (10).
KeywordsUlcerative Colitis Local Immune Response Helper Activity Inflame Mucosa Strategic Defense Initiative
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