Role of the Galt Contrasuppressor T Cell Circuit in Isotype-Specific Immunoregulation
Contrasuppression has been shown to be an important regulatory mechanism where mediation of T helper (Th) and T suppressor (Ts) cell activities are balanced in order to maintain appropriate immune responses in the host. In this regard, the functions of T contrasuppressor (Tes)cells have been described in a number of experimental systems including the enhancement of in vitro anti-sheep erythrocyte (SRBC) responses, the adoptive transfer of contact sensitivity to hapten, the regulation of B cell responses to type 3 pneumococcal polysaccharide and in the abrogation of systemic unresponsiveness (1–5). Effector Tes cells in these systems share the phenotypic characteristics of being Lyt-1+”, -2− and I-J+, and binding to Vicia villosa lectin (6).
KeywordsAdoptive Transfer Oral Tolerance Cell Pathway Tolerant Mouse Contrasuppressor Cell
Unable to display preview. Download preview PDF.
- 6.D.R. Green and W. Ptak. Contrasuppression in the mouse. Immunol. Today 7: 81 (1986).Google Scholar
- 9.K. Kitamura, H. Kiyono, K. Fujihashi, J.H. Eldridge, D.R. Green and J.R. McGhee. Contrasuppressor cells which break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+) and B cells. (Submitted for publication).Google Scholar
- 10.K. Kitamura, H. Kiyono, K. Fujihashi, J.H. Eldridge, K.W. Beagley and J.R. McGhee. Isotype-specific immunoregulation: systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses. (Submitted for publication).Google Scholar