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Role of the Galt Contrasuppressor T Cell Circuit in Isotype-Specific Immunoregulation

  • Kohtaro Fujihashi
  • Hiroshi Kiyono
  • Kenneth W. Beagley
  • John H. Eldridge
  • Jerry R. McGhee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

Contrasuppression has been shown to be an important regulatory mechanism where mediation of T helper (Th) and T suppressor (Ts) cell activities are balanced in order to maintain appropriate immune responses in the host. In this regard, the functions of T contrasuppressor (Tes)cells have been described in a number of experimental systems including the enhancement of in vitro anti-sheep erythrocyte (SRBC) responses, the adoptive transfer of contact sensitivity to hapten, the regulation of B cell responses to type 3 pneumococcal polysaccharide and in the abrogation of systemic unresponsiveness (1–5). Effector Tes cells in these systems share the phenotypic characteristics of being Lyt-1+”, -2 and I-J+, and binding to Vicia villosa lectin (6).

Keywords

Adoptive Transfer Oral Tolerance Cell Pathway Tolerant Mouse Contrasuppressor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Kohtaro Fujihashi
    • 1
  • Hiroshi Kiyono
    • 1
  • Kenneth W. Beagley
    • 1
  • John H. Eldridge
    • 1
  • Jerry R. McGhee
    • 1
  1. 1.Departments of Microbiology and Oral BiologyUniversity of Alabama at BirminghamBirminghamUSA

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