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T Lymphocyte Precursors Migrate Towards Chemotactic Peptides Secreted by Embryonic or Juvenile Thymus

  • B. A. Imhof
  • M. A. Deugnier
  • T. Itoh
  • J. P. Thiery
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

During embryonic life the thymic rudiment is extensively seeded by invading hemopoietic precursors that give rise to mature T cells (1). In birds thymus, colonization by precursor cells is limited to two defined time periods of embryonic development (2). The first hemopoietic precursor cells appear at day 5 in the thymus of quail embryos. At this stage of development the precursors were enriched in the perithymic region. These precursors are often in contact with endothelial cells of the jugular vein, a prefered site of extravasation; they are also dispersed within the mesenchymal tissue around the thymus, and adhere to the basal lamina that separates the thymus from the mesenchyme (3).

Keywords

Conditioned Medium Boyden Chamber Thymic Epithelial Cell Chemotactic Migration Chemotactic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. A. Imhof
    • 1
  • M. A. Deugnier
    • 1
  • T. Itoh
    • 2
  • J. P. Thiery
    • 1
  1. 1.Physiopathologie du DéveloppementC.N.R.S., Ecole Normale SupérieureParis Cedex 05France
  2. 2.Tohoku University School of MedicineSendai 980Japan

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