Hev Development and Trypsin-Inhibitable Localization of Lymphocytes in the Reaction to Intradermal Pha: a Receptor-Dependent Immigration and Possible Model for Peripheral CMI Reactions?
Lymphocyte recirculation is essential for the efficient recognition of antigenic challenge in the organised lymphoid tissues and the periphery. Lymphocyte entry into most organised lymphoid tissues such as the lymph nodes (LN), Peyer’s patches (PP)(1) tonsils, tongue papillae and thymus(2) is inhibitable by trypsin(l,3), apparently involving the interaction of protein receptors on the circulating lymphocytes with determinants on specialized post capillary venular (PCV) endothelial cells (1). This interaction is also involved in the lymphocyte localization in granulomata and rheumatoid joints (chronic inflammatory tissue)(4) but not in spleen, lung and liver(1,3) or the minor traffic in other tissues, none of which is significantly reduced by trypsinisation. It is probable that the lymphocyte receptors and endothelial cell (EC) determinants involved in active entry into different LN types, into PP and into chronic inflammatory tissue are different(1,4).
KeywordsMacroscopic Reaction Superficial Inguinal Lymph Node Ventral Abdomen increaSing Volume Label Lymphocyte
Unable to display preview. Download preview PDF.
- 2.Binns R.M. & Pabst R. Migration and homing of lymphoid cells, Vol. II Ch.16, CRC Press (in press).Google Scholar
- 3.Binns R.M. & Licence S.T. These proceedings.Google Scholar
- 5.Binns R.M., Pabst R. & Licence S.T. Swine in Biomedical Research, Vol 3, 1837, Plenum N.Y. (1986).Google Scholar
- 6.Binns R.M. & Licence S.T. Microenvironments in the lymphoid system, p.661, Plenum N.Y. (1985).Google Scholar
- 7.Blecha F., Pollman D. & Nichols D. J. Anim Sci. 56, 396 (1983).Google Scholar
- 10.Binns R.M. Mongr. in Allergy 16, 37 (1980).Google Scholar