Advertisement

Hev Development and Trypsin-Inhibitable Localization of Lymphocytes in the Reaction to Intradermal Pha: a Receptor-Dependent Immigration and Possible Model for Peripheral CMI Reactions?

  • R. M. Binns
  • J. F. T. Griffin
  • S. T. Licence
  • F. B. P. Wooding
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

Lymphocyte recirculation is essential for the efficient recognition of antigenic challenge in the organised lymphoid tissues and the periphery. Lymphocyte entry into most organised lymphoid tissues such as the lymph nodes (LN), Peyer’s patches (PP)(1) tonsils, tongue papillae and thymus(2) is inhibitable by trypsin(l,3), apparently involving the interaction of protein receptors on the circulating lymphocytes with determinants on specialized post capillary venular (PCV) endothelial cells (1). This interaction is also involved in the lymphocyte localization in granulomata and rheumatoid joints (chronic inflammatory tissue)(4) but not in spleen, lung and liver(1,3) or the minor traffic in other tissues, none of which is significantly reduced by trypsinisation. It is probable that the lymphocyte receptors and endothelial cell (EC) determinants involved in active entry into different LN types, into PP and into chronic inflammatory tissue are different(1,4).

Keywords

Macroscopic Reaction Superficial Inguinal Lymph Node Ventral Abdomen increaSing Volume Label Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Woodruff J.J., Clarke L.M. & Chin Y.H. Ann. Rev. Immunol. 5, 201 (1987).CrossRefGoogle Scholar
  2. 2.
    Binns R.M. & Pabst R. Migration and homing of lymphoid cells, Vol. II Ch.16, CRC Press (in press).Google Scholar
  3. 3.
    Binns R.M. & Licence S.T. These proceedings.Google Scholar
  4. 4.
    Jalkanen E., Steere A.C., Fox R.I. & Butcher E.C. Science 233, 556 (1986).PubMedCrossRefGoogle Scholar
  5. 5.
    Binns R.M., Pabst R. & Licence S.T. Swine in Biomedical Research, Vol 3, 1837, Plenum N.Y. (1986).Google Scholar
  6. 6.
    Binns R.M. & Licence S.T. Microenvironments in the lymphoid system, p.661, Plenum N.Y. (1985).Google Scholar
  7. 7.
    Blecha F., Pollman D. & Nichols D. J. Anim Sci. 56, 396 (1983).Google Scholar
  8. 8.
    Binns R.M. Vet. Immunol. Immunopath 3, 95, (1982).CrossRefGoogle Scholar
  9. 9.
    Wooding F.B.P. Biol. Reprod. 22, 357, (1980).PubMedGoogle Scholar
  10. 10.
    Binns R.M. Mongr. in Allergy 16, 37 (1980).Google Scholar
  11. 11.
    Rannie G.H., Smith M.E. & Ford w.L. Nature 267, 520, (1977).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • R. M. Binns
    • 1
  • J. F. T. Griffin
    • 1
  • S. T. Licence
    • 1
  • F. B. P. Wooding
    • 1
  1. 1.Immunology DepartmentAFRC Institute of Animal Physiology and Genetics ResearchCambridgeUK

Personalised recommendations