Reversibility of Loss of Homing Receptor Expression Following Activation
The ability of lymphocytes to recirculate from peripheral blood to lymphoid tissue is necessary in order to maintain an effective immune response, irrespective of an antigen’s port of entry. Recirculation and homing to lymph nodes (LN) and Peyer’s patches (PP) is initiated by the binding of cells to specialized post-capillary high endothelial venules (HEV’s), followed by their passage through the vessel walls into the surrounding lymphoid tissue.
KeywordsSpleen Cell Blast Cell Transferrin Receptor Effective Immune Response Homing Receptor
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