Reversibility of Loss of Homing Receptor Expression Following Activation

  • Thomas M. Jung
  • Morris O. Dailey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The ability of lymphocytes to recirculate from peripheral blood to lymphoid tissue is necessary in order to maintain an effective immune response, irrespective of an antigen’s port of entry. Recirculation and homing to lymph nodes (LN) and Peyer’s patches (PP) is initiated by the binding of cells to specialized post-capillary high endothelial venules (HEV’s), followed by their passage through the vessel walls into the surrounding lymphoid tissue.


Spleen Cell Blast Cell Transferrin Receptor Effective Immune Response Homing Receptor 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Thomas M. Jung
    • 1
  • Morris O. Dailey
    • 1
  1. 1.Departments of Pathology and MicrobiologyUniversity of Iowa, College of MedicineIowa CityUSA

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