B Cell Precursor Populations in Fetal and Neonatal Rat Liver: Frequency, Topography and Antigenic Phenotype

  • G. J. Veldhuis
  • D. Opstelten
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


In rodents and man B lymphocyte development starts in fetal liver, and gradually shifts to the bone marrow where it is maintained throughout life (1). The immediate precursors of newly formed surface IgM bearing B cells are pre-B cells defined by the presence of μ heavy chains (but not light chains) in the cytoplasm only (1).


Fetal Liver Adult Bone Marrow Fetal Liver Cell Neonatal Liver Precursor Population 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • G. J. Veldhuis
    • 1
  • D. Opstelten
    • 1
  1. 1.Department of HistologyState University GroningenThe Netherlands

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