Are Lymphokine Activated Killer Cells a Possible Form of Leukaemia Immunotherapy?
The culture of freshly isolated lymphocytes for three to five days in vitro with a lymphokine preparation rich in interleukin 2 (IL-2), results in the generation of effector cells capable of lysing a variety of tumour cells1. This phenomenon has been described as lymphokine activated killing (LAK) and represents a lytic system distinct from that of natural killer (NK) cells2 and cytotoxic T lymphocytes3. Subsequent studies have revealed that LAK cells mainly arise from non-B, non-T lymphoid cell precursors and are capable of expanding for short times both in vivo and in vitro when stimulated by IL-24.
KeywordsNatural Killer Peripheral Blood Mononuclear Cell Acute Leukaemia Cytosine Arabinoside Activate Killer Cell
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