The Target Cells for Rat NK Cells among Allogeneic Bone Marrow Cells

  • B. Rolstad
  • S. Fossum
  • H. B. Benestad
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The mechanisms governing the rejection of bone marrow allografts in mammals are complex, and may in addition to adaptive immune responses mediated by T and B cells also involve non-adaptive, NK cell mediated rejection mechanisms (Cudkowicz and Bennet, 1971; Kiessling et al., 1977; Lotzová, 1977). Thus, cloned NK cells can adoptively transfer the resistance to bone marrow allografts to NK-deficient recipients (Warner and Dennert, 1982), and NK cells are able to inhibit the proliferation of committed haematopoietic precursors after coculture in vitro (Bordignon et al., 1985).


Bone Marrow Cell Natural Killer Cell Activity Large Granular Lymphocyte Allogeneic Lymphocyte Target Cell Ratio 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • B. Rolstad
    • 1
  • S. Fossum
    • 1
  • H. B. Benestad
    • 2
  1. 1.Institute of AnatomyUniversity of OsloOslo 1Norway
  2. 2.Institute of PhysiologyUniversity of OsloOslo 1Norway

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