The Target Cells for Rat NK Cells among Allogeneic Bone Marrow Cells
The mechanisms governing the rejection of bone marrow allografts in mammals are complex, and may in addition to adaptive immune responses mediated by T and B cells also involve non-adaptive, NK cell mediated rejection mechanisms (Cudkowicz and Bennet, 1971; Kiessling et al., 1977; Lotzová, 1977). Thus, cloned NK cells can adoptively transfer the resistance to bone marrow allografts to NK-deficient recipients (Warner and Dennert, 1982), and NK cells are able to inhibit the proliferation of committed haematopoietic precursors after coculture in vitro (Bordignon et al., 1985).
KeywordsBone Marrow Cell Natural Killer Cell Activity Large Granular Lymphocyte Allogeneic Lymphocyte Target Cell Ratio
Unable to display preview. Download preview PDF.