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Inhibition of Splenic T Lymphocytes and Accessory Cell Interaction by Anti-Mac-1 (Monoclonal Antibody to Complement Receptor Type 3)

  • S. El Rouby
  • M. Papiernik
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

Macrophages express a family of structurally and functionally related glycoproteins: LFA-1, Mac-1 and P150,95, which are involved in cell adhesion (1). Each of these molecules contains a different a subunit but they share an identical β subunit (1–2). LFA-1 mediates the attachment of macrophages to tumor cells and the binding of cytotoxic cells to targets (3,1,4). Mac-1 antigen is identical to complement receptor type 3 (CR3) which mediates adhesion of monocytes and granulocytes to C3bi-sensitized particles (5,6). In addition recent findings suggest the role of Mac-1 in the activation of mouse peritoneal macrophages (7).

Keywords

Accessory Cell Mixed Lymphocyte Reaction Mouse Peritoneal Macrophage Mitogeneic Response Mixed Lymphocyte Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    T.A. Springer, D. Davignon, M.K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. Immunol. Rev. 68: 171 (1982).PubMedCrossRefGoogle Scholar
  2. 2.
    F. Sanchez-Madrid, J.A. Nagy, E. Robbins, P. Simon, and T.A. Springer. J. Exp. Med. 158: 1785 (1983).PubMedCrossRefGoogle Scholar
  3. 3.
    G.S. Strassmann, T.A. Springer, S.D. Somers, and D.O. Adams. J. Immunol. 136: 4328 (1986).PubMedGoogle Scholar
  4. 4.
    D. Davignon, E. Martz, T. Reynolds, K. Kurzinger, and T.A. Springer. J. Immunol. 127: 590 (1981).PubMedGoogle Scholar
  5. 5.
    D.I. Beller, T.A. Springer, and R.D. Schreiber. J. Exp. Med. 156: 1000 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    S.D. Wright, P.E. Rao, W.C. Van Voorhis, L.S. Craigmyle, K. Iida, M.A. Talle, G. Goldstein, and S.C. Silverstein. Proc. Natl. Acad. Sci. USA 80: 5699 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    A. Ding, S.D. Wright, and C. Nathan. J. Exp. Med. 165: 733 (1987).PubMedCrossRefGoogle Scholar
  8. 8.
    M. Papiernik, B. Nabarra, W. Savino, C. Pontoux, and S. Barbey. Eur. J. Immunol. 13: 147 (1983).PubMedCrossRefGoogle Scholar
  9. 9.
    S. El Rouby, F. Praz, L. Halbwachs-Mecarelli, and M. Papiernik. J. Immunol. 134: 3625 (1985).PubMedGoogle Scholar
  10. 10.
    S. El Rouby. Doctorat d’Etat Thesis, Faculty of Science, University of Pierre et Marie Curie, Paris 6ème, France (1987).Google Scholar
  11. 11.
    T.A. Springer, G. Galfre, D.S. Sécher, and C. Milstein. Eur. J. Immunol. 9: 301 (1979).PubMedCrossRefGoogle Scholar
  12. 12.
    M. Bekoff, T. Kakiuchi, and H.M. Grey. J. Immunol. 134: 1337 (1985).PubMedGoogle Scholar
  13. 13.
    G. Schuler, and R.M. Steinman. J. Exp. Med. 161: 526 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • S. El Rouby
    • 1
  • M. Papiernik
    • 1
  1. 1.INSERM U 25Hôpital NeckerParisFrance

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