Inhibition of Splenic T Lymphocytes and Accessory Cell Interaction by Anti-Mac-1 (Monoclonal Antibody to Complement Receptor Type 3)
Macrophages express a family of structurally and functionally related glycoproteins: LFA-1, Mac-1 and P150,95, which are involved in cell adhesion (1). Each of these molecules contains a different a subunit but they share an identical β subunit (1–2). LFA-1 mediates the attachment of macrophages to tumor cells and the binding of cytotoxic cells to targets (3,1,4). Mac-1 antigen is identical to complement receptor type 3 (CR3) which mediates adhesion of monocytes and granulocytes to C3bi-sensitized particles (5,6). In addition recent findings suggest the role of Mac-1 in the activation of mouse peritoneal macrophages (7).
KeywordsAccessory Cell Mixed Lymphocyte Reaction Mouse Peritoneal Macrophage Mitogeneic Response Mixed Lymphocyte Culture
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- 10.S. El Rouby. Doctorat d’Etat Thesis, Faculty of Science, University of Pierre et Marie Curie, Paris 6ème, France (1987).Google Scholar