Synovial T Cells Detect Polymorphism of Class II HLA Antigens

  • J. S. H. Gaston
  • P. Life
  • P. A. Bacon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Rheumatoid arthritis (RA) is associated with the class II MHC antigen HLA-DR41. Since MHC antigens control recognition of antigens by T cells2, this association with HLA-DR4 strongly implies that a T cellmediated immune response is important in the pathogenesis of RA. This response may occur within the joint since extensive T cell infiltration is characteristic of RA synovium3,4.


Rheumatoid Arthritis Patient Proliferative Response Stimulator Cell Juvenile Rheumatoid Arthritis Reactive Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. S. H. Gaston
    • 1
  • P. Life
    • 1
  • P. A. Bacon
    • 1
  1. 1.Department of Rheumatology, The Medical SchoolUniversity of BirminghamBirminghamUK

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