Synovial T Cells Detect Polymorphism of Class II HLA Antigens
Rheumatoid arthritis (RA) is associated with the class II MHC antigen HLA-DR41. Since MHC antigens control recognition of antigens by T cells2, this association with HLA-DR4 strongly implies that a T cellmediated immune response is important in the pathogenesis of RA. This response may occur within the joint since extensive T cell infiltration is characteristic of RA synovium3,4.
KeywordsRheumatoid Arthritis Patient Proliferative Response Stimulator Cell Juvenile Rheumatoid Arthritis Reactive Arthritis
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- 12.G.A. Dos Reis and E.M. Shevach, Analysis of autoreactive I regionrestricted T cell colonics isolated from guinea pig syngeneic mixed leukocyte reaction and from immune responses to conventional foreign antigens, Eur. J. Immunol. 15: 466 (1985).Google Scholar