Thymus Homing and Recostitution in Split Dose Irradiated Preleukemic Mice

  • M. P. Defresne
  • C. Humblet
  • R. Greimers
  • J. Boniver
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The incidence of thymic lymphomas in C57BL/Ka mice treated with four weekly irradiations of 1.75 Gy, reaches more than 90% (1), The tumors appear after a long latent period (4 to 9 months), during which the thymuses contain preneoplastic cells (called preleukemic cells) requiring the thymic microenvironment for their progression into frank neoplasia (2).


Bone Marrow Cell Scientific Research Foundation Normal Thymus Thymic Lymphoma Normal Bone Marrow Cell 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • M. P. Defresne
    • 1
    • 2
  • C. Humblet
    • 2
  • R. Greimers
    • 2
  • J. Boniver
    • 2
  1. 1.Belgian National Scientific Research FoundationBelgique
  2. 2.Laboratory of Pathological Anatomy B.23Université de LiègeLiègeBelgique

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