Thymic Hyperplasia in Myasthenia Gravis: Immuno-Histological Abnormalities and Responsiveness to Recombinant IL2

  • S. Cohen-Kaminsky
  • S. Berrih-Aknin
  • D. Safar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Myasthenia Gravis (MG) is an autoimmune disorder of neuromuscular transmission characterized by the presence of autoantibodies directed against acetylcholine receptor (AChR), which are detected in more than 85 % of patients’ sera (1). The role of the thymus in MG has been strongly suggested by the favorable clinical effects of thymectomy and by the high incidence of thymic abnormalities (15–20 % thymomas and 50 % hyperplastic thymuses) (2).


Double Label Experiment Thymic Hyperplasia Thymic Lymphocyte Thymic Abnormality High Proliferative Response 


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • S. Cohen-Kaminsky
    • 1
  • S. Berrih-Aknin
    • 1
  • D. Safar
    • 1
  1. 1.Centre Chirurgical Marie-LannelongueCNRS UA 04-1159Le Plessis-RobinsonFrance

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