Structural and Cellular Changes in the Mouse Thymus During Pregnancy

  • Ann G. Clarke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


During pregnancy in all mammals, including man, there is a massive loss of lymphocytes from the thymus. This is reflected in an excessive involution, with decreases in weight and in the numbers of thymocytes. At the end of pregnancy in the mouse, the thymus has lost 75% of its weight and cells. Involution continues during lactation, after which the thymus regenerates, becomes repopulated with lymphocytes, and regains its original size.


Normal Pregnancy Perivascular Space Involuted Thymus Thymus Weight Virgin Animal 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ann G. Clarke
    • 1
  1. 1.Department of Obstetrics and GynaecologyUniversity of Nottingham Queen’s Medical CentreNottinghamUK

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