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Structural and Cellular Changes in the Mouse Thymus During Pregnancy

  • Ann G. Clarke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

During pregnancy in all mammals, including man, there is a massive loss of lymphocytes from the thymus. This is reflected in an excessive involution, with decreases in weight and in the numbers of thymocytes. At the end of pregnancy in the mouse, the thymus has lost 75% of its weight and cells. Involution continues during lactation, after which the thymus regenerates, becomes repopulated with lymphocytes, and regains its original size.

Keywords

Normal Pregnancy Perivascular Space Involuted Thymus Thymus Weight Virgin Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baroni, C.D., Valtieri, M., Stoppacciaro, A., Ruco, L.P., Uccini, S. and Ricci, C., 1983, The human thymus in ageing: histologic involution paralleled by increased mitogen response and by enrichment of OKT3+ lymphocytes, Immunol. 50: 519.Google Scholar
  2. 2.
    Chambers, S.P. and Clarke, A.G., 1979, Measurements of thymus weight, lumbar node weight and progesterone levels in syngeneically pregnant, allogeneically pregnant and pseudopregnant mice, J. Reprod. Fertil., 55: 309.PubMedCrossRefGoogle Scholar
  3. 3.
    Clarke, A.G., 1979, Pregnancy-induced involution of the thymus can be prevented by immunizing with paternal skin grafts: a stain-dependent effect, Clin. Exp. Immunol., 35: 421.PubMedGoogle Scholar
  4. 4.
    Clarke, A.G., 1984, Immunological studies on pregnancy in the mouse, in: “Immunological Aspects of Reproduction in Mammals“, D.B. Crighton, ed., Butterworths, London.Google Scholar
  5. 5.
    Clarke, A.G. and MacLennan, K.A., 1986, The many facets of thymic involution, Immunol. Today, 7: 204.CrossRefGoogle Scholar
  6. 6.
    Cobbold, S.P., Jayasuriya, A., Nash, A., Prospero, T.D. and Waldman, H., 1984, Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature, 312: 549.Google Scholar
  7. 7.
    Galfre, G., Milstein, C. and Wright, B., 1979, Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse lgG, Nature, 277: 131.PubMedCrossRefGoogle Scholar
  8. 8.
    Gordon, H. and Sweets, H.H., 1936, A simple method for the silver impregnation of reticulum, Am. J. Pathol., 12: 545.PubMedGoogle Scholar
  9. 9.
    Kendall, M., 1984, Have we underestimated the importance of the thymus in man? Experientia, 40: 1181.PubMedCrossRefGoogle Scholar
  10. 10.
    Lancier, L.L. and Warner, N.L., 1981, Paraformaldehyde fixation of haematopoietic cells for quantitative flow cytometry (FACS) analysis. J. Immunol. Methods, 47: 25.CrossRefGoogle Scholar
  11. 11.
    Nandi, S., 1959, Hormonal control of mamogenesis and lactogenesis in the C3H/He Crgl mouse. Univ. Calif. Publ. Zool., 65: 1.Google Scholar
  12. 12.
    Scollay, R. and Shortrnan, K., 1983, Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers, Thymus, 5: 245.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ann G. Clarke
    • 1
  1. 1.Department of Obstetrics and GynaecologyUniversity of Nottingham Queen’s Medical CentreNottinghamUK

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