M Receptor and Differentiation of T Lymphocytes in the Developing Human Thymus

  • Katarina Isaković
  • Tatjana Matejić
  • B. D. Janković
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


In earlier studies we demonstrated that prothymocytes in the 14–22-week-old fetal liver contained receptors for mouse erythrocytes (1,2), and that M receptor is a differentiation marker of fetal and infant thymocytes (3). This report deals with the study of thymocyte subsets and T cell differentiation in human fetal and infant thymus, in which M receptor was used as a marker of T cells. Further, to provide a more composite picture of thymocyte differentiation and compesate the limitations of experimental methods in detecting the cells coexpressing more than two markers, a mathematical probability method defining various membrane phenotypes was used. On the basis of experimentally obtained data and results of regression analysis, a hypothetical pathway of T cell differentiation within the thymus was proposed.


Human Thymus Fetal Thymus Composite Picture Undergo Heart Surgery Thymocyte Differentiation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Katarina Isaković
    • 1
  • Tatjana Matejić
    • 1
  • B. D. Janković
    • 1
  1. 1.Immunology Research CenterBelgradeYugoslavia

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