M Receptor and Differentiation of T Lymphocytes in the Developing Human Thymus
In earlier studies we demonstrated that prothymocytes in the 14–22-week-old fetal liver contained receptors for mouse erythrocytes (1,2), and that M receptor is a differentiation marker of fetal and infant thymocytes (3). This report deals with the study of thymocyte subsets and T cell differentiation in human fetal and infant thymus, in which M receptor was used as a marker of T cells. Further, to provide a more composite picture of thymocyte differentiation and compesate the limitations of experimental methods in detecting the cells coexpressing more than two markers, a mathematical probability method defining various membrane phenotypes was used. On the basis of experimentally obtained data and results of regression analysis, a hypothetical pathway of T cell differentiation within the thymus was proposed.
KeywordsHuman Thymus Fetal Thymus Composite Picture Undergo Heart Surgery Thymocyte Differentiation
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