Advertisement

M Receptor and Differentiation of T Lymphocytes in the Developing Human Thymus

  • Katarina Isaković
  • Tatjana Matejić
  • B. D. Janković
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

In earlier studies we demonstrated that prothymocytes in the 14–22-week-old fetal liver contained receptors for mouse erythrocytes (1,2), and that M receptor is a differentiation marker of fetal and infant thymocytes (3). This report deals with the study of thymocyte subsets and T cell differentiation in human fetal and infant thymus, in which M receptor was used as a marker of T cells. Further, to provide a more composite picture of thymocyte differentiation and compesate the limitations of experimental methods in detecting the cells coexpressing more than two markers, a mathematical probability method defining various membrane phenotypes was used. On the basis of experimentally obtained data and results of regression analysis, a hypothetical pathway of T cell differentiation within the thymus was proposed.

Keywords

Human Thymus Fetal Thymus Composite Picture Undergo Heart Surgery Thymocyte Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    B.D. Janković, K. lsaković, and T. Matejić, in: “Microenvironments in the Lymphoid System”, p.901, G.G.B. Klaus,ed., Plenum Publishing Co., (1985).Google Scholar
  2. 2.
    K. lsaković, T. Matejić, and B.D. Janković, in: “Microenvironments in the Lymphoid System”, p.909, G.G.B. Klaus, ed., Plenum Publishing Co., (1985).Google Scholar
  3. 3.
    K. Isaković, T. Matejić, G. Terzić, and B.D. Janković. Fed.Proc. 42: 521 (1983).Google Scholar
  4. 4.
    K. lsaković, K. Mitrović, B.M. Marković, M. Rajević, and B.D. Jankovic. J.Immunol.Meth. 7: 359 (1975).CrossRefGoogle Scholar
  5. 5.
    D.E. Parks, M.D. Doyle, and W.O. Weigie. J.Immunol. 119: 1923 (1977).PubMedGoogle Scholar
  6. 6.
    J.D. Griffin, R.P. Beveridge, and S.F. Schlossman. Blood, 60: 30 (1982).PubMedGoogle Scholar
  7. 7.
    W.W. Cooley, and P.R. Lohnes. Multivalent Procedures for the Behavioral Sciences, John Wiley and Sons (1962).Google Scholar
  8. 8.
    B. Ostle, Statistics in Research, The Iowa State College Press (1954).Google Scholar
  9. 9.
    S. Berrish, C. Boussuges, J.P. Binet, and J.F. Bach. Cell.Immunol. 74: 260 (1982).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Katarina Isaković
    • 1
  • Tatjana Matejić
    • 1
  • B. D. Janković
    • 1
  1. 1.Immunology Research CenterBelgradeYugoslavia

Personalised recommendations