A Study of Early Events During T Cell Differentiation in Thymic Grafted Nude Mice
Major progress has been made in characterizing the genes coding for the T cell antigen receptor and their products. The T cell receptor is a heterodimeric transmembrane glycoprotein consisting of disulphide linked and β subunits and the genes encoding these proteins are arranged in a similar manner to those coding the immunoglobulins1. The genes are in a germ-line configuration in all tissues except for the T cell lineage where DNA rearrangements contribute to the generation of diversity of receptors. Recent evidence indicates that diversification of the T cell receptor repertoire by gene rearrangement occurs within the thymus, long considered the primary site of T cell production2,3. Furthermore, processes occuring within the thymus are seen as essential in moulding the repertoire of the emergent T cell pool by imprinting MHC restriction specificity and inducing self tolerance4.
KeywordsNude Mouse Spleen Cell Minor Histocompatibility Antigen Fetal Thymus Thymic Epithelium
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