Production of Interleukin 1 (IL1) by Human Thymic Epithelial Cells (TEC)

  • S. Cohen-Kaminsky
  • S. Berrih-Aknin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


The thymic microenvironment plays a central role in T cell proliferation and maturation, both through the secretion of thymic hormones (1), and through direct interactions between T cell precursors and their stromal partners (2, 3). Thymic epithelial cells (TEC) are ideally suited, both anatomically and functionally, as microenvironmental cells able to differentiate and educate T cells. Our investigations regarding human TEC have shown that cultures of thymic epithelium are an interesting model for phenotypic and functional studies. We have shown that cultured TEC express keratin, produce extracellular matrix components (4), and secrete the thymic hormone, thymulin (5). As a part of our effort to understand the relationship between developing T lymphocytes and the epithelial microenvironment of the thymus, we have shown that TEC class II antigen expression is lost in culture and regulated by recombinant interferon-(6). Interleukin 1 (IL1) represents a family of polypeptide cytokines which mediate many aspects of the immune and inflamatory responses (reviewed in ref. 7). Although they were originally considered to be strictly the product of activated monocytes or macrophages, a number of recent reports have indicated that other cell types may produce ILl-like molecules (8-11).


Thymic Epithelial Cell Secondary Culture Thymic Hormone Thymic Epithelium Thymic Microenvironment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    J.F. Bach, and C. Cardaux C. Prog. Allergy, 21: 342 (1976).CrossRefGoogle Scholar
  2. 2.
    O. Stutman. Immunol. Rev., 42: 138 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    H. Wekerle, V.P. Ketelsen and M. Emst. J. Exp. Med, 151: 925 (1980).PubMedCrossRefGoogle Scholar
  4. 4.
    S. Berrih, W. Savino and S. Cohen. J. Histoch. Cytoch., 33: 655 (1985).CrossRefGoogle Scholar
  5. 5.
    S. Cohen, S. Berrih, M. Dardenne and J.F. Bach. Thymus, 8: 109, 1986.PubMedGoogle Scholar
  6. 6.
    S. Berrih, F. Arenzana-Seisdedos, S. Cohen, R. Devos, D. Charron and J.L. Virelizier. J. Immunol., 135: 1165 (1985).PubMedGoogle Scholar
  7. 7.
    C.A. Dinarello. Infect. Dis. Rev., 6: 51, 1984.CrossRefGoogle Scholar
  8. 8.
    P. Miossec, D. Cavender and M. Ziff. J. Immunol., 136: 2486 (1986).PubMedGoogle Scholar
  9. 9.
    D.N. Sauder. Lymph. Res., 3: 145 (1984).Google Scholar
  10. 10.
    A. Fontana, F. Kristensen, R. Dubs, D. Gemsa and E. Weber. J. Immunol., 29: 2413 (1982).Google Scholar
  11. 11.
    K. Matsushima, G. Tosato, D. Benjamin and J.J. Oppenheim. Cell. Immunol., 94: 418 (1985).PubMedCrossRefGoogle Scholar
  12. 12.
    E.L. Reinherz. Immunol. Today, 6: 75 (1985).CrossRefGoogle Scholar
  13. 13.
    K.L. Rock and F. Benacerraf. J. Immunol, 132: 1654 (1984).PubMedGoogle Scholar
  14. 14.
    S.B. Mizel Mol Immunol, 17: 571 (1981).CrossRefGoogle Scholar
  15. 15.
    P.T. Le, D.T. Tuck, C.A. Dinarello, B.F. Haynes and K.H. Singer. J. Immunol, 138: 2520 (1987).PubMedGoogle Scholar
  16. 16.
    R. Gallily, M. Zeira and I. Stain. Immunol, 55: 165 (1985).Google Scholar
  17. 17.
    D.I. Beller and E.R. Unanue. J. Immunol, 124: 1433 (1980).PubMedGoogle Scholar
  18. 18.
    R.C. Newton. J. Leuko. Biol, 39: 299Google Scholar
  19. 19.
    M. Papiernik and F. Homo-delarche. Eur. J. Immunol, 13: 689 (1983).PubMedCrossRefGoogle Scholar
  20. 20.
    J.L. Lepe-Zuniga and I. Gery. Clin. Immunol Immunopathol, 31: 222 (1984).PubMedCrossRefGoogle Scholar
  21. 21.
    B.F. Haynes; R.M. Scearle, D.F. Lobach and L.L. Hensley. J. Exp. Med., 159: 1149 (1984).PubMedCrossRefGoogle Scholar
  22. 22.
    R.A. De Maagd, W.A. Mackenzie, HJ. Schuurman, M.A. Ritter, K.M. Price, R. Broekhuizen and L. Kater. Immunology, 54: 745 (1985).PubMedGoogle Scholar
  23. 23.
    K.H. Singer, L.S. Wolf, D.F. Lobach, S.M. Denning, D.T. Tuck, A.L. Robertson and B.F. Haynes. Proc. Natl. Acad. Sci. (USA), 83: 6588 (1986).CrossRefGoogle Scholar
  24. 24.
    S.T. Denning, D.T. Tuck, K.H. Singer and B.F. Haynes. Clin. Res., 34: 669A (1986).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • S. Cohen-Kaminsky
    • 1
  • S. Berrih-Aknin
    • 1
  1. 1.Centre Chirurgical Marie-Lannelongue, CNRS UA 04-1159Le PlessisFrance

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