The Germinal Center Precursor Cell is Surface μ and σ Positive

  • H. G. Seijen
  • J. C. A. M. Bun
  • A. S. Wubbena
  • K. G. Löhlefink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)


Primary follicles in peripheral lymphoid organs consist of large aggregates of B cells, which express both IgM and IgD on their surface (1). Upon antigenic stimulation germinal centers (GC) arise within the follicles; these GC are thought to be instrumental in the production of B memory cells (2).The cells constituting the germinal centers express only small amounts of surface IgM and sometimes of other Ig classes (3),but not of IgD (1). The question then arises whether the sIgM+ —sIgD+ cells of primary follicles indeed are the precursor cells of germinal centers.


Germinal Center Cell Fraction Primary Follicle Germinal Center Reaction Peripheral Lymphoid Organ 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. G. Seijen
    • 1
  • J. C. A. M. Bun
    • 1
  • A. S. Wubbena
    • 1
  • K. G. Löhlefink
    • 1
  1. 1.Department of HistologyUniversity of GroningenGroningenThe Netherlands

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