Advertisement

Memory B Cells but not Virgin B Cells are Activated in Germinal Centers

  • David Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 237)

Abstract

In chimaeras constructed by transferring K-allotype distinct DNP-haemocyanin-primed thoracic duct lymphocytes (TDL) into irradiated (hind limb bone marrow shielded) recipients the activation of virgin (host allotype) B cells is often transient falling to negligible levels within 14 days (1). The lower affinity of antigen receptors on virgin B cells compared to memory B cells precludes their continued activation as antigen becomes limiting. However, as antibody levels rise antigen is re-localised into follicles in the form of immune complex (2,3). Recently it has been shown that virgin B cells after transfer do not migrate into follicular structures, in contrast to transferred TDL (4). This raises the possibility that virgin and memory B cell activation occurs at different sites. When the supply of antigen is high (soon after immunisation) both virgin and memory B cells are activated at extra-foilicular sites but as antigen levels fall and re-localisation onto follicular dendritic cells (FDC) occurs, only memory B cells gain access to the antigen supply.

Keywords

Immune Complex Donor Cell Antigen Receptor Follicular Dendritic Cell Spider Crab 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D Gray, ICM MacLennan and PJL Lane. Eur. J. Immunol. 16 641 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    RG White, DC Henderson, MB Eslami and KH Nielsen. Immunology 28 1 (1975).PubMedGoogle Scholar
  3. 3.
    M Papamichail, C Gutierrez, P Embling, P Johnson, EJ Holborrow and MB Pepys. Scand. J. Immunol. 4 343 (1975).PubMedCrossRefGoogle Scholar
  4. 4.
    JE Lortan, CA Roobottom, S Oldfield and ICM MacLennan. Eur. J. Immunol. (1987) in press.Google Scholar
  5. 5.
    PJL Lane, D Gray, S Oldfield and ICM MacLennan. Eur. J. Immunol. 16 1569 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    ICM MacLennan and D Gray. Immunol. Rev. 91 61 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    D Gray. Population of kinetics of rat peripheral B cells (submitted) (1987).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David Gray
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

Personalised recommendations